2. Apoptosis
  3. Apoptosis
  4. (Rac)-Idroxioleic acid

(Rac)-Idroxioleic acid  (Synonyms: 2-Hydroxyoleic acid; 2-OHOA)

Cat. No.: HY-129467 Purity: ≥98.0%
COA Handling Instructions

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(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.

For research use only. We do not sell to patients.

(Rac)-Idroxioleic acid Chemical Structure

(Rac)-Idroxioleic acid Chemical Structure

CAS No. : 56472-29-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 213 In-stock
Solution
10 mM * 1 mL in DMSO USD 213 In-stock
Solid
1 mg USD 65 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
25 mg USD 430 In-stock
50 mg USD 690 In-stock
100 mg USD 1100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

(Rac)-Idroxioleic acid Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

In Vitro

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Idroxioleic acid Related Antibodies

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
In Vivo

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.
Molecular Weight

298.46

Formula

C18H34O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCC(O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (335.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3505 mL 16.7527 mL 33.5053 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3505 mL 16.7527 mL 33.5053 mL 83.7633 mL
5 mM 0.6701 mL 3.3505 mL 6.7011 mL 16.7527 mL
10 mM 0.3351 mL 1.6753 mL 3.3505 mL 8.3763 mL
15 mM 0.2234 mL 1.1168 mL 2.2337 mL 5.5842 mL
20 mM 0.1675 mL 0.8376 mL 1.6753 mL 4.1882 mL
25 mM 0.1340 mL 0.6701 mL 1.3402 mL 3.3505 mL
30 mM 0.1117 mL 0.5584 mL 1.1168 mL 2.7921 mL
40 mM 0.0838 mL 0.4188 mL 0.8376 mL 2.0941 mL
50 mM 0.0670 mL 0.3351 mL 0.6701 mL 1.6753 mL
60 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3961 mL
80 mM 0.0419 mL 0.2094 mL 0.4188 mL 1.0470 mL
100 mM 0.0335 mL 0.1675 mL 0.3351 mL 0.8376 mL
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(Rac)-Idroxioleic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Idroxioleic acid56472-29-82-Hydroxyoleic acid 2-OHOAApoptosisoleicacidplasmamembraneInhibitorinhibitorinhibit

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