(Rac)-Idroxioleic acid
Based on 1 Customer Validation
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 56472-29-8
- Formula: C18H34O3
- Molecular Weight:298.46
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:25 μM, 50 μM, 75 μM
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Incubation Time:24 hours, 48 hours, 72 hours
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Result:Impaired Jurkat cell growth in a time- and concentration-dependent manner.
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Cell Line:Jurkat cells
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Concentration:25 μM, 50 μM
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Incubation Time:72 hours
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Result:Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)[1]
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Dosage:600 mg/kg
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Administration:Oral administration; daily; for 21 days
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Result:Markedly and significantly inhibited tumour growth.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 56472-29-8
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Appearance Solid
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Molecular Weight 298.46
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Formula C18H34O3
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCC(O)C(O)=O
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Synonyms
2-Hydroxyoleic acid; 2-OHOA; LAM561
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (335.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3505 mL | 16.7527 mL | 33.5053 mL | 83.7633 mL |
| 5 mM | 0.6701 mL | 3.3505 mL | 6.7011 mL | 16.7527 mL | |
| 10 mM | 0.3351 mL | 1.6753 mL | 3.3505 mL | 8.3763 mL | |
| 15 mM | 0.2234 mL | 1.1168 mL | 2.2337 mL | 5.5842 mL | |
| 20 mM | 0.1675 mL | 0.8376 mL | 1.6753 mL | 4.1882 mL | |
| 25 mM | 0.1340 mL | 0.6701 mL | 1.3402 mL | 3.3505 mL | |
| 30 mM | 0.1117 mL | 0.5584 mL | 1.1168 mL | 2.7921 mL | |
| 40 mM | 0.0838 mL | 0.4188 mL | 0.8376 mL | 2.0941 mL | |
| 50 mM | 0.0670 mL | 0.3351 mL | 0.6701 mL | 1.6753 mL | |
| 60 mM | 0.0558 mL | 0.2792 mL | 0.5584 mL | 1.3961 mL | |
| 80 mM | 0.0419 mL | 0.2094 mL | 0.4188 mL | 1.0470 mL | |
| 100 mM | 0.0335 mL | 0.1675 mL | 0.3351 mL | 0.8376 mL |
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