(Rac)-Idroxioleic acid sodium
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect.
For research use only. We do not sell to patients.
- CAS No.: 1229114-68-4
- Formula: C18H33NaO3
- Molecular Weight:320.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Rac)-Idroxioleic acid sodium (25-75 μM; 72 h) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid sodium (25-50 μM; 72 h) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:25 μM, 50 μM, 75 μM
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Incubation Time:24 hours, 48 hours, 72 hours
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Result:Impaired Jurkat cell growth in a time- and concentration-dependent manner.
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Cell Line:Jurkat cells
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Concentration:25 μM, 50 μM
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Incubation Time:72 hours
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Result:Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)[1]
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Dosage:600 mg/kg
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Administration:Oral administration; daily; for 21 days
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Result:Markedly and significantly inhibited tumour growth.
Chemical Information
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CAS No. 1229114-68-4
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Molecular Weight 320.44
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Formula C18H33NaO3
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SMILES
O=C(O[Na])C(O)CCCCCC/C=C\CCCCCCCC
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Synonyms
2-Hydroxyoleic acid sodium; 2-OHOA sodium; LAM561 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Idroxioleic acid sodium Related Classifications
HY-129467A Related Classifications
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