2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. SCH-900271

SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing.

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SCH-900271 Chemical Structure

SCH-900271 Chemical Structure

CAS No. : 915210-50-3

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Description

SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1].

IC50 & Target

EC50: 2.0 nM (hu-GPR109a), 96 nM (hu-GPR109b), 8.0 nM (rat-GPR109a), 6.0 nM (m-GPR109a) and 5.0 nM (dog-GPR109a)[1]
Molecular Weight

276.29

Formula

C14H16N2O4
CAS No.
SMILES

O=C1NC2=C(C(CCCC3(C)CC3)=CC(O2)=O)C(N1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCH-900271 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH-900271915210-50-3SCH900271SCH 900271nAChRNicotinic acetylcholine receptorsOrallynicotinic acid receptorNARhu-GPR109afatty acidFFAflushingInhibitorinhibitorinhibit

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