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Cat. No.: HY-N10071

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Poricoic acid G

Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans.

For research use only. We do not sell to patients.

CAS No.: 415724-84-4
Formula: C₃₀H₄₆O₅
Molecular Weight:486.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Poricoic acid G Chemical Structure

CAS No.: 415724-84-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
AZ-521 cell line	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
DU-145	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
HL-60	GI₅₀	39.3 nM Compound: 1, poricoic acid G	Growth inhibition of human HL60 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HL60 cells after 48 hrs by sulforhodamine B assay	[PMID: 11975480]
HL-60	GI₅₀	39.3 nM Compound: 124	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 23092389]
HL-60	GI₅₀	39.3 nM Compound: 79	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 14987072]
HL-60	IC₅₀	32.6 μM Compound: 14	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 19746919]
HL-60	IC₅₀	32.6 μM Compound: 3a	Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
OVCAR-3	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
PANC-1	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]
SK-BR-3	IC₅₀	>100 μM Compound: 3a	Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21250700]

Chemical Information

CAS No. 415724-84-4
Molecular Weight 486.68
Formula C₃₀H₄₆O₅
SMILES

C/C(C)=C\CC[C@@H](C(O)=O)[C@H]1[C@H](O)C[C@]2(C)[C@]1(C)CCC3=C2CC[C@@H](C(C)=C)[C@@]3(CCC(O)=O)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Poria cocos
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Motohiko Ukiya, et al. Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos. J Nat Prod. 2002 Apr;65(4):462-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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