1. Anti-infection
  2. Bacterial
    Parasite
  3. Hexyl gallate

Hexyl gallate (Synonyms: Hexyl 3,4,5-trihydroxybenzoate)

Cat. No.: HY-135652 Purity: 99.89%
Handling Instructions

Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR. Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM.

For research use only. We do not sell to patients.

Hexyl gallate Chemical Structure

Hexyl gallate Chemical Structure

CAS No. : 1087-26-9

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Solution
10 mM * 1 mL in DMSO USD 50 In-stock
Estimated Time of Arrival: December 31
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200 mg USD 135 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR[1]. Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM[2].

In Vitro

Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) inhibits only Rhl-dependent production of rhamnolipid and pyocyanin by inhibiting RhlR, without affecting elastase production and biofilm formation which are regulated by the Las system.Hexyl gallates inhibits pigment production at 10-30 μM, but also exhibited antibacterial activity. Hexyl gallates also exhibits antibacterial activity against CV026 cells. Hexyl gallates inhibits only N-butanoyl homoserine lactone (BHL) production at 100 and 300 μM without affecting N-(3-oxododecanoyl)-l-homoserine lactone (OdDHL) and 2-heptyl-3-hydroxy-4(1 H) quinolone (PQS) production[1].
Hexyl gallates, an antimicrobial alternative to copper compounds, inhibits Xanthomonas citri growth in a dose-response manner, showing a more pronounced activity at the range of 30-50 μg/ml, and it targets the membrane of X. citri[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.28

Formula

C₁₃H₁₈O₅

CAS No.
SMILES

O=C(OCCCCCC)C1=CC(O)=C(O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (163.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

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Keywords:

Hexyl gallateHexyl 3,4,5-trihydroxybenzoateBacterialParasitegallicacidantimalarialderivativeantibacterialrhamnolipidpyocyaninInhibitorinhibitorinhibit

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Product Name:
Hexyl gallate
Cat. No.:
HY-135652
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