5-Hydroxyferulic acid

Name: 5-Hydroxyferulic acid
Brand: MedChemExpress
SKU: HY-133068
Rating: 4.5 (1 reviews)

Cat. No.: HY-133068 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

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5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.

For research use only. We do not sell to patients.

5-Hydroxyferulic acid Chemical Structure

CAS No. : 1782-55-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 462	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 462	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Hydroxyferulic acid:

(E)-5-Hydroxyferulic acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

The product of the alfalfa Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase (COMT) catalyzed methylation of 5-Hydroxyferulic acid is sinapic acid. 5-Hydroxyferulic acid O-methyltransferase activities (pkat mg-1 protein) in stem material from COMT downregulates transgenic alfalfa^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.18

Formula

C₁₀H₁₀O₅

CAS No.

1782-55-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)/C=C/C1=CC(OC)=C(O)C(O)=C1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (475.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7578 mL	23.7891 mL	47.5783 mL
5 mM	0.9516 mL	4.7578 mL	9.5157 mL
10 mM	0.4758 mL	2.3789 mL	4.7578 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. K Parvathi, et al. Substrate Preferences of O-methyltransferases in Alfalfa Suggest New Pathways for 3-O-methylation of Monolignols. Plant J. 2001 Jan;25(2):193-202. [Content Brief]

[2]. S Maury, et al. Tobacco O-methyltransferases Involved in Phenylpropanoid Metabolism. The Different Caffeoyl-Coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and Caffeic acid/5-hydroxyferulic Acid 3/5-O-methyltransferase Classes Have Distinct Substrate Specificities and Expression Patterns. Plant Physiol. 1999 Sep;121(1):215-24. [Content Brief]

[3]. Inoue, et al. Substrate Preferences of Caffeic acid/5-hydroxyferulic Acid 3/5-O-methyltransferases in Developing Stems of Alfalfa (Medicago Sativa L.). Arch Biochem Biophys. 2000 Mar 1;375(1):175-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7578 mL	23.7891 mL	47.5783 mL	118.9457 mL
	5 mM	0.9516 mL	4.7578 mL	9.5157 mL	23.7891 mL
	10 mM	0.4758 mL	2.3789 mL	4.7578 mL	11.8946 mL
	15 mM	0.3172 mL	1.5859 mL	3.1719 mL	7.9297 mL
	20 mM	0.2379 mL	1.1895 mL	2.3789 mL	5.9473 mL
	25 mM	0.1903 mL	0.9516 mL	1.9031 mL	4.7578 mL
	30 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9649 mL
	40 mM	0.1189 mL	0.5947 mL	1.1895 mL	2.9736 mL
	50 mM	0.0952 mL	0.4758 mL	0.9516 mL	2.3789 mL
	60 mM	0.0793 mL	0.3965 mL	0.7930 mL	1.9824 mL
	80 mM	0.0595 mL	0.2974 mL	0.5947 mL	1.4868 mL
	100 mM	0.0476 mL	0.2379 mL	0.4758 mL	1.1895 mL