L-Homocysteic acid
Based on 1 publication(s) in Google Scholar
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 14857-77-3
- Formula: C4H9NO5S
- Molecular Weight:183.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Homocysteic acid
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Biological Activity
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NMDA Receptor 14 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
<100 μM
Compound: 4
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Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active
|
[PMID: 15801843] |
L-Homocysteic acid activates NMDA receptor with an EC50 value of 14 μM[1].
L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells[1].
L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction in ex vivo chick embryo retina[2].
L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino rats of the Wistar strain[4]
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Dosage:4, 5.5, 8, 11 mM/kg
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Administration:Intraperitoneal injection, daily for 14 days
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Result:Induced flexion seizures at 4 mmol/kg.
Led to intense tail flicking, pivoting, and locomotion.
Decreased ECoG (electrocorticograms) activity for 5-9 min.
Chemical Information
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CAS No. 14857-77-3
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Appearance Solid
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Molecular Weight 183.18
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Formula C4H9NO5S
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Color White to off-white
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Synonyms
L-HCA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
2025 Apr 26:S0891-5849(25)00253-9. PMID: 40294854
Solvent & Solubility
H2O : ≥ 100 mg/mL (545.91 mM)
DMSO : 50 mg/mL (272.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82(5):2820-6. [Content Brief]
[2]. J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19(5):597-602. [Content Brief]
[3]. B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855(2):292-7. [Content Brief]
[4]. P Mares, et al. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats. [Content Brief]
[5]. Katherine L Nicholson, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009 Apr;203(2):441-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.4591 mL | 27.2956 mL | 54.5911 mL | 136.4778 mL |
| 5 mM | 1.0918 mL | 5.4591 mL | 10.9182 mL | 27.2956 mL | |
| 10 mM | 0.5459 mL | 2.7296 mL | 5.4591 mL | 13.6478 mL | |
| 15 mM | 0.3639 mL | 1.8197 mL | 3.6394 mL | 9.0985 mL | |
| 20 mM | 0.2730 mL | 1.3648 mL | 2.7296 mL | 6.8239 mL | |
| 25 mM | 0.2184 mL | 1.0918 mL | 2.1836 mL | 5.4591 mL | |
| 30 mM | 0.1820 mL | 0.9099 mL | 1.8197 mL | 4.5493 mL | |
| 40 mM | 0.1365 mL | 0.6824 mL | 1.3648 mL | 3.4119 mL | |
| 50 mM | 0.1092 mL | 0.5459 mL | 1.0918 mL | 2.7296 mL | |
| 60 mM | 0.0910 mL | 0.4549 mL | 0.9099 mL | 2.2746 mL | |
| 80 mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.7060 mL | |
| 100 mM | 0.0546 mL | 0.2730 mL | 0.5459 mL | 1.3648 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Homocysteic acid Related Classifications
HY-138903 Related Classifications
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