14857-77-3
14857-77-3
Chemical Structure
L-Homocysteic acid
Synonym(s): L-HCA
- CAS No.: 14857-77-3
- Formula:C4H9NO5S
- Molecular Weight:183.18
IUPAC Name: (S)-2-amino-4-sulfobutanoic acid
InChIKey: VBOQYPQEPHKASR-VKHMYHEASA-N
SMILES: O=C(O)[C@@H](N)CCS(=O)(O)=O
Biological Activity: L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-Homocysteic acid | 98.0% | L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. | ||||||||||||||||||||
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References
- [1]. M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82(5):2820-6. [Content Brief]
- [2]. J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19(5):597-602. [Content Brief]
- [3]. B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855(2):292-7. [Content Brief]
