2. L-Methionine-DL-sulfoximine

L-Methionine-DL-sulfoximine  (Synonyms: MSX; MSO)

Cat. No.: HY-B1692 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia.

For research use only. We do not sell to patients.

L-Methionine-DL-sulfoximine Chemical Structure

L-Methionine-DL-sulfoximine Chemical Structure

CAS No. : 15985-39-4

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Based on 1 publication(s) in Google Scholar

L-Methionine-DL-sulfoximine Related Antibodies

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Description

L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia.

Molecular Weight

180.23

Formula

C5H12N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCS(=N)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (277.42 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5485 mL 27.7423 mL 55.4847 mL
5 mM 1.1097 mL 5.5485 mL 11.0969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (554.85 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (111 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5485 mL 27.7423 mL 55.4847 mL 138.7116 mL
5 mM 1.1097 mL 5.5485 mL 11.0969 mL 27.7423 mL
10 mM 0.5548 mL 2.7742 mL 5.5485 mL 13.8712 mL
15 mM 0.3699 mL 1.8495 mL 3.6990 mL 9.2474 mL
20 mM 0.2774 mL 1.3871 mL 2.7742 mL 6.9356 mL
25 mM 0.2219 mL 1.1097 mL 2.2194 mL 5.5485 mL
30 mM 0.1849 mL 0.9247 mL 1.8495 mL 4.6237 mL
40 mM 0.1387 mL 0.6936 mL 1.3871 mL 3.4678 mL
50 mM 0.1110 mL 0.5548 mL 1.1097 mL 2.7742 mL
60 mM 0.0925 mL 0.4624 mL 0.9247 mL 2.3119 mL
80 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7339 mL
100 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3871 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Methionine-DL-sulfoximine15985-39-4MSX MSOInhibitorinhibitorinhibit

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