2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Repaglinide

Repaglinide  (Synonyms: AG-EE 623ZW)

Cat. No.: HY-15209 Purity: 99.88%
COA Handling Instructions

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

For research use only. We do not sell to patients.

Repaglinide Chemical Structure

Repaglinide Chemical Structure

CAS No. : 135062-02-1

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Solution
10 mM * 1 mL in DMSO USD 80 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 80 In-stock
Solid
50 mg USD 73 In-stock
100 mg USD 131 In-stock
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Other Forms of Repaglinide:

Repaglinide Related Antibodies

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  • Biological Activity

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Description

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus[1].

In Vitro

Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Repaglinide Related Antibodies
In Vivo

Repaglinide (AG-EE 623ZW) is very rapidly absorbed (tmax less than 1 hour) with a t1/2 of less than one hour. Furthermore, Repaglinide is inactivated in the liver and more than 90 % excreted via the bile. Repaglinide (1 mg/kg p.o.) is effective (P<0.001) as an insulin-releasing agent in a rat model (low-dose streptozotocin) of type 2 diabetes.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

452.59

Appearance

Solid

Formula

C27H36N2O4
CAS No.
SMILES

CC(C)C[C@H](NC(CC1=CC(OCC)=C(C(O)=O)C=C1)=O)C2=CC=CC=C2N3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (110.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2095 mL 11.0475 mL 22.0951 mL
5 mM 0.4419 mL 2.2095 mL 4.4190 mL
10 mM 0.2210 mL 1.1048 mL 2.2095 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Repaglinide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Repaglinide135062-02-1AG-EE 623ZWPotassium ChannelKcsAcarbamoylmethylbenzoicacidCMBAdiabetesinsulinsecretagoguetype-2mellitus.Inhibitorinhibitorinhibit

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