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Repaglinide (Synonyms: AG-EE 623ZW)

Cat. No.: HY-15209 Purity: 99.80%
Handling Instructions

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.

For research use only. We do not sell to patients.

Repaglinide Chemical Structure

Repaglinide Chemical Structure

CAS No. : 135062-02-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 119 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus[1].

In Vitro

Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Repaglinide (AG-EE 623ZW) is very rapidly absorbed (tmax less than 1 hour) with a t1/2 of less than one hour. Furthermore, Repaglinide is inactivated in the liver and more than 90 % excreted via the bile. Repaglinide (1 mg/kg p.o.) is effective (P<0.001) as an insulin-releasing agent in a rat model (low-dose streptozotocin) of type 2 diabetes.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

452.59

Formula

C₂₇H₃₆N₂O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (110.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2095 mL 11.0475 mL 22.0951 mL
5 mM 0.4419 mL 2.2095 mL 4.4190 mL
10 mM 0.2210 mL 1.1048 mL 2.2095 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Repaglinide
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HY-15209
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