2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. 3-Methylglutaconic acid

3-Methylglutaconic acid  (Synonyms: β-Methylglutaconic acid)

Cat. No.: HY-139427 Purity: 99.38%
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3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research.

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3-Methylglutaconic acid Chemical Structure

3-Methylglutaconic acid Chemical Structure

CAS No. : 5746-90-7

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Other Forms of 3-Methylglutaconic acid:

3-Methylglutaconic acid Related Antibodies

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Description

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

In Vitro

3-Methylglutaconic acid (0.1-5.0 mM, 1 h) induces lipid oxidative damage and antioxidants (TRO, MEL and SOD plus CAT) prevent the lipid peroxidation at higher doses of 5 mM in rat cerebral cortex supernatants[1].
3-Methylglutaconic acid (0.1-5.0 mM, 1 h) induces protein oxidative damage and diminishes non-enzymatic antioxidant defenses in rat cerebral cortex supernatants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Methylglutaconic acid Related Antibodies
In Vivo
Animal Model: Male Sprague-Dawley rats and male Hartley guinea-pigs[2]
Dosage: 0.16 mL/kg, 90 min
Administration: Intraperitoneal injection (i.p.)
Result: Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat)
Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs).
Animal Model: Male Wistar rats[3]
Dosage: 45mg/kg for single dose, 4days
Administration: Intraperitoneal injection (i.p.)
Result: Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells.
Molecular Weight

144.13

Formula

C6H8O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(/C=C(CC(O)=O)\C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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3-Methylglutaconic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Methylglutaconic acid5746-90-7β-Methylglutaconic acidGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptoroxidative stresscerebral cortexInhibitorinhibitorinhibit

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