2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. (R)-Lisofylline

(R)-Lisofylline  (Synonyms: (R)-Lisophylline)

Cat. No.: HY-109854A Purity: 99.99%
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(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

For research use only. We do not sell to patients.

(R)-Lisofylline Chemical Structure

(R)-Lisofylline Chemical Structure

CAS No. : 100324-81-0

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Based on 1 publication(s) in Google Scholar

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(R)-Lisofylline Related Antibodies

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Description

(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research[1][2].

IC50 & Target

IC50: 0.6 µM (Lysophosphatidic acid acyltransferase)[1]
STAT4[1]
In Vitro

(R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Lisofylline Related Antibodies
In Vivo

(R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets from NOD mice, as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test[1].
(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling. (R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice[1].
(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs[1].
(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or Escherichia coli[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

280.32

Formula

C13H20N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCC[C@H](O)C)N(C)C2=C(N(C)C=N2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (356.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5674 mL 17.8368 mL 35.6735 mL
5 mM 0.7135 mL 3.5674 mL 7.1347 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

COA (248 KB) HNMR (243 KB) RP-HPLC (246 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5674 mL 17.8368 mL 35.6735 mL 89.1838 mL
5 mM 0.7135 mL 3.5674 mL 7.1347 mL 17.8368 mL
10 mM 0.3567 mL 1.7837 mL 3.5674 mL 8.9184 mL
15 mM 0.2378 mL 1.1891 mL 2.3782 mL 5.9456 mL
20 mM 0.1784 mL 0.8918 mL 1.7837 mL 4.4592 mL
25 mM 0.1427 mL 0.7135 mL 1.4269 mL 3.5674 mL
30 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
40 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
50 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
60 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
80 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
100 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8918 mL
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(R)-Lisofylline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Lisofylline100324-81-0(R)-LisophyllineSTATPentoxifyllinemetaboliteanti-inflammatoryimmunomodulatorIFN-γSTAT4IL-12diabetesLPSlysophosphatidicacidacyltransferase,Inhibitorinhibitorinhibit

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