1. JAK/STAT Signaling
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  3. (R)-Lisofylline

(R)-Lisofylline (Synonyms: (R)-Lisophylline)

Cat. No.: HY-109854A
Handling Instructions

(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

For research use only. We do not sell to patients.

(R)-Lisofylline Chemical Structure

(R)-Lisofylline Chemical Structure

CAS No. : 100324-81-0

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Description

(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research[1][2].

IC50 & Target

IC50: 0.6 µM (Lysophosphatidic acid acyltransferase)[1]
STAT4[1]

In Vitro

(R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro[3].

In Vivo

(R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets from NOD mice, as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test[1].
(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling. (R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice[1].
(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs[1].
(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or Escherichia coli[1].

Molecular Weight

280.32

Formula

C₁₃H₂₀N₄O₃

CAS No.

100324-81-0

SMILES

O=C(N1CCCC[[email protected]](O)C)N(C)C2=C(N(C)C=N2)C1=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(R)-Lisofylline(R)-LisophyllineSTATPentoxifyllinemetaboliteanti-inflammatoryimmunomodulatorIFN-γSTAT4IL-12diabetesLPSlysophosphatidicacidacyltransferase,Inhibitorinhibitorinhibit

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