STAT4

By Targets:	Small Interfering RNA (siRNA) (1) STAT (1)
By Research Areas:	Inflammation/Immunology (1) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 µM and interrupts IL-12 signaling-mediated *STAT4* activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .

HY-RS13891

STAT4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT4 Human Pre-designed siRNA Set A STAT4 Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	423 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

423 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Compare	Product Name	Species	Source

HY-P76664

	STAT4 Protein, Human (sf9, His) Signal transducer and activator of transcription 4; STAT4	Human	Sf9 insect cells
	The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of STAT4 Protein, Human (sf9, His) is 748 a.a., with molecular weight of ~87 kDa.


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HY-P80903

STAT4 Antibody STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, IP	Human
STAT4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 86 kDa, targeting to STAT4. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

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