Search Result

Results for "

immunomodulator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (11) Autophagy (1) Bacterial (1) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) EGFR (1) Endogenous Metabolite (2) Enterovirus (1) Free Fatty Acid Receptor (1) Fungal (1) HBV (1) HCV (1) HIV (3) HPV (1) HSV (3) IFNAR (2) Interleukin Related (2) Isotope-Labeled Compounds (2) Ligands for E3 Ligase (6) LPL Receptor (1) Molecular Glues (6) NF-κB (8) NOD-like Receptor (NLR) (3) Parasite (2) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) Progesterone Receptor (1) Prostaglandin Receptor (2) STAT (1) TGF-beta/Smad (1) Toll-like Receptor (TLR) (5) VEGFR (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (2) Endocrinology (1) Infection (9) Inflammation/Immunology (43) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124411

Lobenzarit

Others Inflammation/Immunology

Lobenzarit, an immunomodulator, possesses anti-oxidative .
HY-145609

Debotansine

Others Inflammation/Immunology Cancer

Debotansine is a immunomodulator and antineoplastic .

Lobenzarit	Others	Inflammation/Immunology
Lobenzarit, an immunomodulator, possesses anti-oxidative .

Debotansine	Others	Inflammation/Immunology Cancer
Debotansine is a immunomodulator and antineoplastic .

HY-147247

Fosimdesonide	Others	Inflammation/Immunology
Fosimdesonide, a small molecule of adalimumab fosimdesonide, is a potent *immunomodulator. Fosimdesonide shows anti-inflammatory* activity .

HY-119527

Conagenin

Others Inflammation/Immunology Cancer

Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

Conagenin	Others	Inflammation/Immunology Cancer
Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

HY-P99295

Imgatuzumab RG 7160; RO 5083945; Anti-EGFR Recombinant Antibody	EGFR	Cancer
Imgatuzumab (RG 7160) is a humanized monoclonal antibody against the EGFR. Imgatuzumab acts as an immunomodulator. Imgatuzumab can be used in research of cancer .

HY-P99606

Cirevetmab ZTS-00521426	TGF-beta/Smad	Inflammation/Immunology
Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 caninized monoclonal antibody. Cirevetmab is an immunomodulator .

HY-139718

IMD-biphenylB	NF-κB	Inflammation/Immunology
IMD-biphenylB is a potent imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.

HY-131863

Pomalidomide 4'-alkylC8-acid	Ligands for E3 Ligase Apoptosis Molecular Glues	Cancer
Pomalidomide 4'-alkylC8-acid is an E3 ubiquitin ligase ligand-Linker conjugate containing Pomalidomide (HY-10984). Pomalidomide is a third-generation immunomodulator that acts like a molecular glue. Pomalidomide interacts with the E3 ligase cereblon to induce degradation of the essential Ikaros transcription factor .

HY-N10528

3-Fucosyllactose 3-Fucosyl-D-lactose	Bacterial Enterovirus	Infection Neurological Disease Inflammation/Immunology
3-Fucosyllactose (3-Fucosyl-D-lactose) is one of the major fucosylated oligosaccharides found in human breast milk. 3-Fucosyllactose shows prebiotic, immunomodulator, neonatal brain development, and antimicrobial function .

HY-150734

ODN 2007	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
ODN 2007, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3' .

HY-161131

Lenalidomide 4'-alkyl-C3-azide	Ligands for E3 Ligase Apoptosis Molecular Glues	Inflammation/Immunology
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-148805

Vonifimod

Others Inflammation/Immunology

Vonifimod is an immunomodulator .
HY-156645

Tegomil fumarate

Others Inflammation/Immunology

Tegomil fumarate is an immunomodulator .

Vonifimod	Others	Inflammation/Immunology
Vonifimod is an immunomodulator .

Tegomil fumarate	Others	Inflammation/Immunology
Tegomil fumarate is an immunomodulator .

HY-13010S

Laquinimod-d5 ABR-215062-d₅	Isotope-Labeled Compounds Apoptosis NF-κB	Inflammation/Immunology
Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-13010

Laquinimod 2 Publications Verification ABR-215062	NF-κB Apoptosis	Inflammation/Immunology
Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-W062904

Laquinimod sodium ABR-215062 sodium	NF-κB Apoptosis	Neurological Disease Inflammation/Immunology
Laquinimod (ABR-215062) sodium, an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod sodium reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod sodium has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-15898

Y-320 3 Publications Verification	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC₅₀ values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .

HY-109098

Parimifasor

LYC30937
Others Inflammation/Immunology

Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.
HY-139714

IMD-vanillin

NF-κB Cancer

IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.
HY-100162

TOK-8801

Others Inflammation/Immunology

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.
HY-101098

PD-1-IN-18

PD-1-IN-18 is a PD1 signaling pathway inhibitor, which acts as an immunomodulator.
HY-139717

IMD-biphenylA

NF-κB Cancer

IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.
HY-P99611

Faralimomab

64G12
IFNAR Inflammation/Immunology

Faralimomab (64G12) is an immunomodulator, and a murine anti-IFNA1 IgG1 mAb .

Parimifasor LYC30937	Others	Inflammation/Immunology
Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

IMD-vanillin	NF-κB	Cancer
IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.

TOK-8801	Others	Inflammation/Immunology
TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.

PD-1-IN-18
PD-1-IN-18 is a PD1 signaling pathway inhibitor, which acts as an immunomodulator.

IMD-biphenylA	NF-κB	Cancer
IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.

Faralimomab 64G12	IFNAR	Inflammation/Immunology
Faralimomab (64G12) is an immunomodulator, and a murine anti-IFNA1 IgG1 mAb .

HY-13666

Levamisole hydrochloride 3 Publications Verification (-)-Tetramisole hydrochloride	Parasite HSV	Infection Neurological Disease
Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV.

HY-N10240

9-Demethyl FR-901235

Others Inflammation/Immunology

9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235 .

9-Demethyl FR-901235	Others	Inflammation/Immunology
9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235 .

HY-N2389

Formosanin C 1 Publications Verification	Apoptosis	Cancer
Formosanin C is a diosgenin saponin isolated from Paris polyphylla and an immunomodulator with antitumor activity. Formosanin C induces apoptosis .

HY-148801

Tamuzimod

LPL Receptor Inflammation/Immunology

Tamuzimod is a potent immunomodulator. Tamuzimod has S1P Receptor modulatory activity with EC₅₀s <1 μM .

Tamuzimod	LPL Receptor	Inflammation/Immunology
Tamuzimod is a potent immunomodulator. Tamuzimod has S1P Receptor modulatory activity with EC₅₀s <1 μM .

HY-139719

IMD-biphenylC	NF-κB	Inflammation/Immunology
IMD-biphenylC is a novel imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.

HY-W011890

Cridanimod 1 Publications Verification	Progesterone Receptor IFNAR	Inflammation/Immunology
Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer .

HY-139716

IMD-catechol	NF-κB	Inflammation/Immunology
IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.

HY-132223

LH1306	PD-1/PD-L1	Inflammation/Immunology Cancer
LH1306 is a C2-symmetric inhibitor of PD-₁/PD-L₁ protein-protein interaction (PPI), with an IC₅₀ value of 25 nM. LH1306 can be used in anti-tumor research .

HY-34386

6(5H)-Phenanthridinone
6(5H)-Phenanthridinone is a potent PARP-1 inhibitor and immunomodulator. 6(5H)-Phenanthridinone inhibits cell proliferation and can be used in cancer research .

HY-13666S

Levamisole-d5 hydrochloride (-)-Tetramisole-d₅ (hydrochloride)	Parasite HSV	Infection Neurological Disease
Levamisole-d₅ (hydrochloride) is the deuterium labeled Levamisole hydrochloride. Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV[1][2].

HY-110102

Atiprimod hydrochloride SKF 106615	Others	Inflammation/Immunology
Atiprimod hydrochloride (SKF 106615) is an orally active immunomodulatory agent that causes phospholipid (PL) accumulation in macrophages .

HY-117602

TLR7 agonist 3	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 3 (Compound 2) is a potent agonist of toll-like receptor 7 (TLR7). TLR7 has an important role in immune activation processes and represents an emerging agent discovery target for the development of immunomodulators .

HY-13682

Mifamurtide 1 Publications Verification MTP-PE; L-MTP-PE; CGP 19835	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide has potential for use in rare disease and osteosarcoma research .

HY-13682B

Mifamurtide sodium 1 Publications Verification MTP-PE sodium; L-MTP-PE sodium; CGP 19835 sodium	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide sodium (MTP-PE sodium), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide sodium is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide sodium has potential for use in rare disease and osteosarcoma research .

HY-13682A

Mifamurtide sodium hydrate MTP-PE sodium hydrate; L-MTP-PE sodium hydrate; CGP 19835 sodium hydrate	Others	Inflammation/Immunology Cancer
Mifamurtide (sodium hydrate) (MTP-PE (sodium hydrate); L-MTP-PE (sodium hydrate); CGP 19835 (sodium hydrate)) is the sodium hydrate of mifamurtide. Mifamurtide is a nonspecific immunomodulator that acts by stimulating immune responses by activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and is used as an insulin sensitizer and may also be used in osteosarcoma research .

HY-P99215

Parsatuzumab Anti-EGFL7; RG 7414	VEGFR	Cancer
Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition .

HY-13682C

Mifamurtide TFA 1 Publications Verification MTP-PE TFA; L-MTP-PE TFA; CGP 19835 TFA	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide TFA has potential for use in rare disease and osteosarcoma research .

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

HY-106055

Murabutide	HIV	Inflammation/Immunology
Murabutide is a safe synthetic *immunomodulator. Murabutide can reduce CD4 and CCR5 receptor expression and secrete high levels of beta-chemokines. Murabutide enhances nonspecific resistance* against viral infections. Murabutide did not affect virus entry, reverse transcriptase activity or early proviral DNA formation in the cytoplasm of infected cells .

HY-129172

PD-1/PD-L1-IN 5 TFA	PD-1/PD-L1	Infection Inflammation/Immunology Cancer
PD-1/PD-L1-IN 5 TFA is a PD-1/PD-L1 protein/protein interaction inhibitor extracted from patent WO2017222976A1, compound Example 1, has an IC₅₀ of ≤100 nM .

HY-W008634

Bropirimine	Toll-like Receptor (TLR)	Cancer
Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract .

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-156649

Vorbipiprant CR6086	Prostaglandin Receptor	Endocrinology
Vorbipiprant (CR6086) is an EP4 receptor antagonist, serving as a targeted immunomodulator. Thus, Vorbipiprant is also a potential immune checkpoint inhibitor, to turn cold tumors into hot tumors. Vorbipiprant also antagonizes PGE2-stimulated cAMP production (IC50=22 nM). Vorbipiprant exhibit striking DMARD effects in rodents, and anti-inflammatory activity to inhibt immune-mediated inflammatory diseases .

HY-125390

SM-360320 CL-087	Toll-like Receptor (TLR)	Inflammation/Immunology
SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response . SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity .

HY-109137

Selgantolimod GS-9688	Toll-like Receptor (TLR) HBV	Infection
Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection .

HY-A0003

Lenalidomide Maximum Cited Publications 32 Publications Verification CC-5013	Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-A0003B

Lenalidomide hemihydrate Maximum Cited Publications 32 Publications Verification CC-5013 hemihydrate	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer
Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10528

3-Fucosyllactose 3-Fucosyl-D-lactose	Infection Structural Classification Polysaccharides Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields Saccharides	Bacterial Enterovirus
3-Fucosyllactose (3-Fucosyl-D-lactose) is one of the major fucosylated oligosaccharides found in human breast milk. 3-Fucosyllactose shows prebiotic, immunomodulator, neonatal brain development, and antimicrobial function .

HY-N2389

Formosanin C 1 Publications Verification	Structural Classification Paris polyphylla Smith var. chinensis (Franch.) Hara Liliaceae Classification of Application Fields Plants Disease Research Fields Saccharides Cancer	Apoptosis
Formosanin C is a diosgenin saponin isolated from Paris polyphylla and an immunomodulator with antitumor activity. Formosanin C induces apoptosis .

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	Cardiovascular Disease Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	VEGFR HCV Endogenous Metabolite
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

HY-119527

Conagenin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

HY-N10240

9-Demethyl FR-901235	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Inflammation/Immunology	Others
9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235 .

HY-B0715

Pentoxifylline Maximum Cited Publications 7 Publications Verification BL-191; PTX; Oxpentifylline	Classification of Application Fields Disease Research Fields Cancer	Phosphodiesterase (PDE) Autophagy HIV
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

Cat. No.	Product Name	Chemical Structure

HY-13010S

Laquinimod-d5

Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].