Dazdotuftide
Dazdotuftide (TRS01) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide can be used in studies related to inflammation and immunoregulation.
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- CAS No.: 2522933-44-2
- 화학식: C43H68N13O13P
- 분자량:1006.05
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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TLR4 |
NRP1 |
Dazdotuftide (TRS01) reduces the production of IL-1β, IL-2, IL-5, IL-6, IL-9, IL-12 (p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNγ, TNFα and GM-CSF in CD3/CD28-activated human PBMCs, with negligible effects on cell viability.[1]
Dazdotuftide reduces the production of IL-1β, IL-6, IL-13 and IL-17A, and decreases CD68 gene expression in inflammatory human temporal artery biopsies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2522933-44-2
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분자량 1006.05
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화학식 C43H68N13O13P
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Synonyms
TRS01
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Vofo BN, et al. Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate. Biomedicines. 2023 May 27;11(6):1562. [Content Brief]
[2]. Tungsattayathitthan U, et al. Emerging therapeutic targets in non-infectious uveitis and scleritis. Frontiers in medicine. 2026;13:1846374. [Content Brief]
[3]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dazdotuftide Related Classifications
HY-P3449 Related Classifications
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