Emerging therapeutic targets in non-infectious uveitis and scleritis

  • Front Med (Lausanne). 2026 May 15:13:1846374. doi: 10.3389/fmed.2026.1846374.
Usanee Tungsattayathitthan  1  2 ,  Debra A Goldstein  1 ,  Timothy M Janetos  1
Affiliations
  • 1. Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  • 2. Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
PMID: 42221086 DOI: 10.3389/fmed.2026.1846374
Abstract

Non-infectious uveitis and scleritis are significant causes of visual impairment, and currently available targeted and effective therapeutic options remain limited. Multiple immunologic pathways are currently under investigation and targeted therapeutics have the potential to change the treatment landscape and improve visual outcomes. This review synthesizes potential upcoming local and systemic treatments for non-infectious uveitis and scleritis with a focus on therapeutics with human data, noting those with the most promising evidence, and areas of gaps in research.

Keywords
biologics; scleritis; therapeutics; treatment; uveitis.
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