2522933-44-2
Chemical Structure
Dazdotuftide
Synonym(s): TRS01
- CAS No.: 2522933-44-2
- Formula:C43H68N13O13P
- Molecular Weight:1006.05
IUPAC Name: sulfuric acid-d2 compound with ammonia-d3 (1:1)
InChIKey: VXUMKMXYKWBBDK-JERYHNGXSA-N
SMILES: C[C@@H](O)[C@H](N)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(O)=O)CC2=CC(/N=N/C3=CC=C(C=C3)OP(OCC[N+](C)(C)C)([O-])=O)=C(C=C2)O)=O)=O)=O)=O)=O
Biological Activity: Dazdotuftide (TRS01) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide can be used in studies related to inflammation and immunoregulation[1][2][3].
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Dazdotuftide | Dazdotuftide (TRS01) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide can be used in studies related to inflammation and immunoregulation. | |||||||||||||||||||||
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- [1]. Vofo BN, et al. Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate. Biomedicines. 2023 May 27;11(6):1562. [Content Brief]
- [2]. Tungsattayathitthan U, et al. Emerging therapeutic targets in non-infectious uveitis and scleritis. Frontiers in medicine. 2026;13:1846374. [Content Brief]
- [3]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical
Keywords
