6(5H)-Phenanthridinone
Based on 1 Customer Validation
6(5H)-Phenanthridinone is a potent PARP-1 inhibitor and immunomodulator. 6(5H)-Phenanthridinone inhibits cell proliferation and can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1015-89-0
- Formula: C13H9NO
- Molecular Weight:195.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Breast Cancer Compound Library
HY-L074
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HY-L173
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HY-L181
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HY-L001V
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| Cortical neurone | EC50 |
2373 nM
Compound: PND
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Neuroprotective activity in mouse mixed cortical cells assessed as reduction in oxygen-glucose deprivation-induced LDH release
Neuroprotective activity in mouse mixed cortical cells assessed as reduction in oxygen-glucose deprivation-induced LDH release
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10.1039/C1MD00021G |
| HEK293 | EC50 |
945 nM
Compound: PND
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Inhibition of human PARP1 in HEK293 cells assessed as prevention of in MNNG-induced ATP depletion
Inhibition of human PARP1 in HEK293 cells assessed as prevention of in MNNG-induced ATP depletion
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10.1039/C1MD00021G |
Chemical Information
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CAS No. 1015-89-0
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Appearance Solid
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Molecular Weight 195.22
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Formula C13H9NO
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Color Light yellow to brown
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SMILES
O=C1NC2=CC=CC=C2C3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 6.67 mg/mL (34.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1224 mL | 25.6121 mL | 51.2243 mL | 128.0606 mL |
| 5 mM | 1.0245 mL | 5.1224 mL | 10.2449 mL | 25.6121 mL | |
| 10 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL | 12.8061 mL | |
| 15 mM | 0.3415 mL | 1.7075 mL | 3.4150 mL | 8.5374 mL | |
| 20 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4030 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0490 mL | 5.1224 mL | |
| 30 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL |
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