1. Others
    Immunology/Inflammation
  2. Progesterone Receptor
    IFNAR
  3. Cridanimod

Cridanimod 

Cat. No.: HY-W011890 Purity: 99.82%
Handling Instructions

Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.

For research use only. We do not sell to patients.

Cridanimod Chemical Structure

Cridanimod Chemical Structure

CAS No. : 38609-97-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer[1][2].

IC50 & Target

PR, IFNα, IFNβ[1]

In Vivo

Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner[1].

Animal Model: Athymic mice with hec50co cells[1]
Dosage: 1, 3, 6 mg
Administration: IM; twice a week
Result: Had a significantly longer survival time.
Clinical Trial
Molecular Weight

253.26

Formula

C₁₅H₁₁NO₃

CAS No.

38609-97-1

SMILES

O=C(O)CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (493.56 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9485 mL 19.7426 mL 39.4851 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL
10 mM 0.3949 mL 1.9743 mL 3.9485 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (8.21 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CridanimodProgesterone ReceptorIFNARNR3C3Interferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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Cridanimod
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HY-W011890
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