2. Protein Tyrosine Kinase/RTK Anti-infection Metabolic Enzyme/Protease
  3. VEGFR HCV Endogenous Metabolite
  4. Oglufanide

Oglufanide  (Synonyms: H-Glu-Trp-OH; L-Glutamyl-L-tryptophan)

Cat. No.: HY-13718 Purity: 99.26%
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Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities.

For research use only. We do not sell to patients.

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Oglufanide Chemical Structure

Oglufanide Chemical Structure

CAS No. : 38101-59-6

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Based on 1 publication(s) in Google Scholar

Oglufanide Related Antibodies

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  • Biological Activity

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Description

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities[1][2][3].

IC50 & Target[1][2]

VEGFR

 

HCV

 

Human Endogenous Metabolite

 

In Vitro

Oglufanide (IM862) (1-1000 μg/mL) exhibits dose dependent inhibition of angiogenesis in the chorioallantoic membrane assay with complete inhibition of β-FGF and VEGF-induced angiogenesis[3].
? Oglufanide (L-glu-L-trp) (0-1000 μg/mL; 5 days) has no effect on the viability of either the tumor cell lines or HUVECs[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oglufanide Related Antibodies
In Vivo

Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograft[4]
Dosage: 1, 10, 50 and 100 mg/kg/day
Administration: Subcutaneous injection, 10 days
Result: Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.
Clinical Trial
Molecular Weight

333.34

Appearance

Solid

Formula

C16H19N3O5
CAS No.
Structure Classification
Initial Source

calf thymus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 15.5 mg/mL (46.50 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9999 mL 14.9997 mL 29.9994 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL
10 mM 0.3000 mL 1.5000 mL 2.9999 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Oglufanide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Oglufanide38101-59-6H-Glu-Trp-OH L-Glutamyl-L-tryptophanVEGFRHCVEndogenous MetaboliteVascular endothelial growth factor receptorHepatitis C virusLewis lung carcinomaM21 human melanomaantitumoranti-angiogenesisInhibitorinhibitorinhibit

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