2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. SM-360320

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

For research use only. We do not sell to patients.

SM-360320 Chemical Structure

SM-360320 Chemical Structure

CAS No. : 226907-52-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 572 In-stock
Solution
10 mM * 1 mL in DMSO USD 572 In-stock
Solid
1 mg USD 250 In-stock
5 mg USD 520 In-stock
10 mg USD 800 In-stock
25 mg USD 1500 In-stock
50 mg USD 2250 In-stock
100 mg USD 3200 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

SM-360320 Related Antibodies

Top Publications Citing Use of Products

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Molecular Weight

315.33

Formula

C15H17N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (396.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1713 mL 15.8564 mL 31.7128 mL
5 mM 0.6343 mL 3.1713 mL 6.3426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1713 mL 15.8564 mL 31.7128 mL 79.2820 mL
5 mM 0.6343 mL 3.1713 mL 6.3426 mL 15.8564 mL
10 mM 0.3171 mL 1.5856 mL 3.1713 mL 7.9282 mL
15 mM 0.2114 mL 1.0571 mL 2.1142 mL 5.2855 mL
20 mM 0.1586 mL 0.7928 mL 1.5856 mL 3.9641 mL
25 mM 0.1269 mL 0.6343 mL 1.2685 mL 3.1713 mL
30 mM 0.1057 mL 0.5285 mL 1.0571 mL 2.6427 mL
40 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
50 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5856 mL
60 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3214 mL
80 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
100 mM 0.0317 mL 0.1586 mL 0.3171 mL 0.7928 mL
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SM-360320 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-360320226907-52-4CL-087SM360320SM 360320CL087CL 087Toll-like Receptor (TLR)oralTLR7antitumor effectDNA vaccinesTh1Inhibitorinhibitorinhibit

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