2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. SM-360320

SM-360320  (Synonyms: CL-087)

Cat. No.: HY-125390 Purity: 98.07%
COA Handling Instructions

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

For research use only. We do not sell to patients.

SM-360320 Chemical Structure

SM-360320 Chemical Structure

CAS No. : 226907-52-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 572 In-stock
Solution
10 mM * 1 mL in DMSO USD 572 In-stock
Solid
1 mg USD 250 In-stock
5 mg USD 520 In-stock
10 mg USD 800 In-stock
25 mg USD 1500 In-stock
50 mg USD 2250 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

SM-360320 Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Molecular Weight

315.33

Appearance

Solid

Formula

C15H17N5O3
CAS No.
SMILES

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (396.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1713 mL 15.8564 mL 31.7128 mL
5 mM 0.6343 mL 3.1713 mL 6.3426 mL
10 mM 0.3171 mL 1.5856 mL 3.1713 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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SM-360320 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SM-360320226907-52-4CL-087SM360320SM 360320CL087CL 087Toll-like Receptor (TLR)oralTLR7antitumor effectDNA vaccinesTh1Inhibitorinhibitorinhibit

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