226907-52-4
Chemical Structure
SM-360320
Synonym(s): CL-087
- CAS No.: 226907-52-4
- Formula:C15H17N5O3
- Molecular Weight:315.33
IUPAC Name: 6-amino-9-benzyl-2-(2-methoxyethoxy)-7,9-dihydro-8H-purin-8-one
InChIKey: YYCDGEZXHXHLGW-UHFFFAOYSA-N
SMILES: COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1
Biological Activity: SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].
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SM-360320 | 99.41% | SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. | ||||||||||||||||||||
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- [1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [Content Brief]
- [2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. [Content Brief]
Keywords
