1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. SM-324405

SM-324405 

Cat. No.: HY-110207
Handling Instructions

SM-324405 is a TLR7 agonist, with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively.

For research use only. We do not sell to patients.

SM-324405 Chemical Structure

SM-324405 Chemical Structure

CAS No. : 677773-91-0

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

SM-324405 is a TLR7 agonist, with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively[1].

In Vitro

SM-324405 is a novel candidate for immunotherapy of allergic diseases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically[1].
SM-324405 exhibits t1/2 of 2.6 min in human plasma[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

385.42

Formula

C₁₉H₂₃N₅O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (129.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5946 mL 12.9729 mL 25.9457 mL
5 mM 0.5189 mL 2.5946 mL 5.1891 mL
10 mM 0.2595 mL 1.2973 mL 2.5946 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
SM-324405
Cat. No.:
HY-110207
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