1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
    IFNAR
  3. SM-276001

SM-276001 

Cat. No.: HY-123291 Purity: 99.71%
Handling Instructions

SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer.

For research use only. We do not sell to patients.

SM-276001 Chemical Structure

SM-276001 Chemical Structure

CAS No. : 473930-22-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2450 In-stock
Estimated Time of Arrival: December 31
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Description

SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].

IC50 & Target

TLR7; IFN[1][2]

In Vitro

SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice[1].
Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells[2].
SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models[2].
SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 and B6C3F1 mice bearing Renca or CT26 tumors[2]
Dosage: 3 mg/kg
Administration: Oral administration twice weekly for 25 days
Result: Significantly reduced disease burden in mice bearing either Renca or CT26 tumors.
Molecular Weight

327.38

Formula

C₁₆H₂₁N₇O

CAS No.

473930-22-2

SMILES

NC1=C2C(N(C(N2)=O)CC3=CN=C(C=C3)C)=NC(NCCCC)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (381.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2728 mL 30.5455 mL
5 mM 0.6109 mL 3.0546 mL 6.1091 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SM-276001SM276001SM 276001Toll-like Receptor (TLR)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorTLR7antitumorimmuneinterferonIFNInhibitorinhibitorinhibit

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Product Name:
SM-276001
Cat. No.:
HY-123291
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