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Referencia número: HY-168157

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TLR7 agonist 26

TLR7 agonist 26 (Compound 4) is a potent Toll-like receptor 7 (TLR7) agonist, with an EC₅₀ of 225.5 nM. TLR7 agonist 26 shows immunopotentiating effects.

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No. CAS: 1641544-09-3
Fòrmula: C₁₇H₁₉N₅O₄
Peso molecular:357.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TLR7 agonist 26 Chemical Structure

No. CAS: 1641544-09-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

TLR7 agonist 26 (Compound 4) is a potent Toll-like receptor 7 (TLR7) agonist, with an EC₅₀ of 225.5 nM. TLR7 agonist 26 shows immunopotentiating effects^[1].

IC₅₀ & Target

TLR7

225.5 nM (EC₅₀)

Ver todos los productos específicos de isoformas Toll-like Receptor (TLR) :

Cellular Effect

Cell Line	Type	Value	Description	References
B cell	EC₅₀	479.6 nM Compound: 3b	Immunostimulatory activity in CFSE-labeled human B cells assessed as TLR7 agonist-induced cell proliferation after 6 days by FACS analysis Immunostimulatory activity in CFSE-labeled human B cells assessed as TLR7 agonist-induced cell proliferation after 6 days by FACS analysis	[PMID: 27476423]

Chemical Information

No. CAS 1641544-09-3
Peso molecular 357.36
Fòrmula C₁₇H₁₉N₅O₄
SMILES

OC1=NC2=C(N)N=C(OCCCC)N=C2N1CC3=CC=C(C(O)=O)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Janež Š, et al. Linker Chemistry and Connectivity Fine-Tune the Immune Response and Kinetic Solubility of Conjugated NOD2/TLR7 Agonists. Bioconjug Chem. 2024 Oct 10. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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TLR7 agonist 26

Ver todos los productos específicos de isoformas Toll-like Receptor (TLR)