1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. 1V209

1V209 (Synonyms: TLR7 agonist T7)

Cat. No.: HY-115400 Purity: 99.52%
Handling Instructions

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity.

For research use only. We do not sell to patients.

1V209 Chemical Structure

1V209 Chemical Structure

CAS No. : 1062444-54-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 91 In-stock
Estimated Time of Arrival: December 31
5 mg USD 115 In-stock
Estimated Time of Arrival: December 31
10 mg USD 195 In-stock
Estimated Time of Arrival: December 31
25 mg USD 410 In-stock
Estimated Time of Arrival: December 31
50 mg USD 700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1210 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity[1][2].

IC50 & Target[1]

TLR7

 

In Vitro

1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells[1].
1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells[1].

In Vivo

The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration[1].

Molecular Weight

359.34

Formula

C₁₆H₁₇N₅O₅

CAS No.

1062444-54-5

SMILES

O=C(O)C1=CC=C(CN2C(NC3=C(N)N=C(OCCOC)N=C23)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (231.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7829 mL 13.9144 mL 27.8288 mL
5 mM 0.5566 mL 2.7829 mL 5.5658 mL
10 mM 0.2783 mL 1.3914 mL 2.7829 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

1V209TLR7 agonist T7Toll-like Receptor (TLR)TumorcancercellintravenousIL-6IP-10MCP-1TNFαpolysaccharidesconjugate,Inhibitorinhibitorinhibit

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Product name:
1V209
Cat. No.:
HY-115400
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