Search Result

Results for "

intravenous

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (1) Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (6) CaSR (3) Cholecystokinin Receptor (1) COX (1) Drug Metabolite (1) Endogenous Metabolite (1) Fluorescent Dye (1) Liposome (1) Molecular Glues (1) Motilin Receptor (1) Neurokinin Receptor (2) P2Y Receptor (2) Parasite (1) PI3K (3) Prostaglandin Receptor (2) Thrombin (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (5) Infection (3) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (5)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Akt (1)

Apoptosis (5)

Bacterial (1)

Biochemical Assay Reagents (6)

CaSR (3)

Cholecystokinin Receptor (1)

COX (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Fluorescent Dye (1)

Liposome (1)

Molecular Glues (1)

Motilin Receptor (1)

Neurokinin Receptor (2)

P2Y Receptor (2)

Parasite (1)

PI3K (3)

Prostaglandin Receptor (2)

Thrombin (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (6)

Endocrinology (5)

Infection (3)

Inflammation/Immunology (5)

Metabolic Disease (6)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117979

Alphadolone

Alfadolone
Others Cancer

Alphadolone is an intravenous anaesthetics. Alphadolone causes general anaesthesia .
HY-148155

Iotroxic acid

Biochemical Assay Reagents Others

Iotroxic acid is an intravenous cholangiographic agent. Iotroxic acid can be used for medical imaging .

Alphadolone Alfadolone	Others	Cancer
Alphadolone is an intravenous anaesthetics. Alphadolone causes general anaesthesia .

Iotroxic acid	Biochemical Assay Reagents	Others
Iotroxic acid is an intravenous cholangiographic agent. Iotroxic acid can be used for medical imaging .

HY-136476A

Mn(II) protoporphyrin IX	Biochemical Assay Reagents	Others
Mn(II) protoporphyrin IX is a potential intravenous paramagnetic magnetic resonance contrast agent. Mn(II) protoporphyrin IX maintains strong paramagnetic properties .

HY-144773A

Loxoprofenol-SRS tromethamine HR1405–01	COX	Inflammation/Immunology
Loxoprofenol-SRS tromethamine (HR1405-01), an active metabolite of Loxoprofen, is a Safe intravenous non-steroidal anti-inflammatory drug (NSAID) with superior anti-inflammatory and analgesic activities .

HY-N10225

Thielavin A	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .

HY-107353

Gadopentetic acid 2 Publications Verification Gd-DTPA; gadolinium complex	Biochemical Assay Reagents	Others
Gadopentetic acid (Gd-DTPA) is a paramagnetic contrast agent. Gadopentetic acid commonly implemented by a bolus intravenous injection in Dynamic contrast-enhanced MRI (DCE-MRI) studies. Gadopentetic acid also can be used for the research of nephrogenic systemic fibrosis (NSF) .

HY-P4154

Bevonescein ALM-488	Fluorescent Dye	Neurological Disease
Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves .

HY-B1657

Fosphenytoin	Others	Neurological Disease
Fosphenytoin is a phosphate ester proagent developed as an alternative to intravenous phenytoin for acute intervention of seizures. Fosphenytoin has advantages including more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites .

HY-B1297

Ceforanide

Ceforanide is a second generation cephalosporin administered intravenously or intramuscularly. Ceforanide has a spectrum of in vitro antibacterial activity .

Ceforanide
Ceforanide is a second generation cephalosporin administered intravenously or intramuscularly. Ceforanide has a spectrum of in vitro antibacterial activity .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-144773

Loxoprofenol-SRS	Drug Metabolite	Inflammation/Immunology
Loxoprofenol-SRS, an active metabolite of Loxoprofen, is a new intravenous NSAID. Loxoprofenol-SRS exhibits significantly stronger anti-inflammatory and analgesic activities .

HY-B2068

Iron sucrose Iron saccharate
Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment .

HY-135578

Artelinic acid	Parasite	Infection
Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .

HY-N6910

Pseudolaric Acid C2	Others	Metabolic Disease
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-11021

Elinogrel PRT060128	P2Y Receptor	Cardiovascular Disease
Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y₁₂ antagonist (IC₅₀=20 nM). It is orally and intravenously available and has potent antiplatelet effects .

HY-N10226

Thielavin B	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Thielavin B is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin B effectively influences the prostaglandin E2 synthesis from the endoperoxide. Thielavin B is significantly effective on carrageenan-induced oedema of rats when administered intravenously .

HY-P5889

Thrombin receptor peptide ligand	Thrombin	Cardiovascular Disease
Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent .

HY-100435

Oxaquin MCB-3837; DNV3837
Oxaquin (MCB-3837) is a injectable proagent that is rapidly converted to the active substance MCB3681 in vivo following intravenous (i.v.) administration, active against Gram-positive bacterial species. Oxaquin (MCB-3837) itself has no antimicrobial effects .

HY-109106A

Upacicalcet sodium	CaSR	Endocrinology
Upacicalcet sodium is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-109106

Upacicalcet	CaSR	Endocrinology
Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-B0302

Etidronic acid 1 Publications Verification Etidronate; HEDPA; HEDP	Apoptosis	Metabolic Disease Cancer
Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water .

HY-109106B

(Rac)-Upacicalcet	CaSR	Endocrinology
(Rac)-Upacicalcet is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT) .

HY-122529

Almurtide	Bacterial	Infection
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus .

HY-121045

Bunitrolol KO 1366	Adrenergic Receptor	Cardiovascular Disease
Bunitrolol is a beta-adrenergic antagonist. Bunitrolol has intrinsic sympathomimetic activity. Bunitrolol can be used for the research of ischemic myocardium .

HY-B0302A

Etidronic acid disodium 1 Publications Verification Etidronate disodium; HEDPA disodium; HEDP disodium
Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water .

HY-105215

FK888	Neurokinin Receptor	Inflammation/Immunology
FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a K_i value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration .

HY-19638

Cangrelor AR-C69931MX
Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist .

HY-14658B

(R)-Thalidomide (R)-(+)-Thalidomide	Others	Metabolic Disease
(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties .

HY-106258

Atilmotin OHM 11638; BAX-ACC 1638; MOT 288	Motilin Receptor	Metabolic Disease
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents .

HY-130522

6β-Prostaglandin I1 6β-PGI1	Others	Others
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID₅₀ (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection) .

HY-137500

NT1-014B	Liposome	Neurological Disease
NT1-014B is a potent NT1-lipidoid encapsulated AmB (amphotericin B). NT1-014B dopes the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. NT1-014B enhances brain delivery through intravenous injection .

HY-19638A

Cangrelor tetrasodium 1 Publications Verification AR-C69931MX tetrasodium	P2Y Receptor	Cardiovascular Disease Inflammation/Immunology
Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist .

HY-112624B

Dextran (MW 70000)	Biochemical Assay Reagents	Others
Dextran (MW 70000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles.

HY-112624C

Dextran (MW 40000)	Biochemical Assay Reagents Endogenous Metabolite	Others
Dextran (MW 40000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles.

HY-15346

Copanlisib Maximum Cited Publications 21 Publications Verification BAY 80-6946	PI3K Apoptosis	Cancer
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity .

HY-14658A

(S)-Thalidomide (S)-(-)-Thalidomide	Apoptosis Molecular Glues	Metabolic Disease Inflammation/Immunology
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects . (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .

HY-15346A

Copanlisib dihydrochloride Maximum Cited Publications 21 Publications Verification BAY 80-6946 dihydrochloride	PI3K Apoptosis	Cancer
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity .

HY-109513

Ioxilan	Biochemical Assay Reagents	Others
Ioxilan is a low-osmolar, nonionic and tri-iodinated diagnostic contrast agent. Ioxilan is also an X-ray contrast agent for excretory urography and contrast enhanced computed tomographic (CECT) imaging of the head and body. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs .

HY-B2227B

Lactate sodium 3 Publications Verification Lactic acid sodium	Others	Metabolic Disease
Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .

HY-115400

1V209 2 Publications Verification TLR7 agonist T7	Toll-like Receptor (TLR)	Cancer
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity .

HY-P0093

Sincalide 3 Publications Verification Cholecystokinin octapeptide; CCK-8; SQ19844
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. CCK‐8 can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-P0093A

Sincalide ammonium 3 Publications Verification Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-163345

5-HT7R antagonist 2

5-HT Receptor

Neurological Disease

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K_i of 67 nM, the IC₅₀ values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
Pharmacokinetic Analysis ICR Male Mice

药代动力学分析

Plasma	Intravenous Administration	Intraperitoneal Administration
T_max (h)	0.08	0.25
T_1/2 (h)	0.77	1.06
C_max (ng/mL)	33.07	156.44
AUC_last (ng·h/mL)	28.31	143.27
CL (L/h/kg)	41.61	-
V_ss (L/kg)	32.43	-
MRT (h)	0.79	0.93
F (%)	50.60

NT1-014B	Drug Delivery
NT1-014B is a potent NT1-lipidoid encapsulated AmB (amphotericin B). NT1-014B dopes the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. NT1-014B enhances brain delivery through intravenous injection .

Cat. No.	Product Name	Target	Research Area