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  2. Parasite
  3. Artelinic acid

Artelinic acid 

Cat. No.: HY-135578
Handling Instructions

Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes.

For research use only. We do not sell to patients.

Artelinic acid Chemical Structure

Artelinic acid Chemical Structure

CAS No. : 120020-26-0

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Description

Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes[1][2].

In Vivo

Artelinic acid (10 mg/kg; i.v.) has an elimination time t1/2 of 0.37 hours, a CL of 14.99 mL/min/kg, a Vss of 9.52 L and a AUC0-12h of 11219 ng h/mL for dogs[1].
Artelinic acid (10 mg/kg; intramuscular) has an elimination time t1/2 of 6.14 hours, a CL of 14.58 mL/min/kg, a Vss of 36.1 L and a AUC0-12h of 96372 ng h/mL for dogs[1].
Artelinic acid (10 mg/kg; oral) has an elimination time t1/2 of 2.21 hours, a CL of 14.6 mL/min/kg, a Vss of 16.2 L and a AUC0-12h of 8839 ng h/mL for dogs[1].

Animal Model: Adult male beagle dogs 3-5 years old[1]
Dosage: 10 mg/kg
Administration: i.v. (Pharmacokinetic Analysis)
Result: Had an elimination time t1/2 of 0.37 hours, a CL of 14.99 mL/min/kg, a Vss of 9.52 L and a AUC0-12h of 11219 ng h/mL for dogs.
Molecular Weight

418.48

Formula

C₂₃H₃₀O₇

CAS No.

120020-26-0

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Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Artelinic acidParasitederivativemalariaanaloguestableantimalarialInhibitorinhibitorinhibit

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Artelinic acid
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