2. GPCR/G Protein
  3. CaSR
  4. Upacicalcet sodium

Upacicalcet sodium is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

For research use only. We do not sell to patients.

Upacicalcet sodium Chemical Structure

Upacicalcet sodium Chemical Structure

CAS No. : 2052969-18-1

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5 mg USD 550 In-stock
10 mg USD 880 In-stock
25 mg USD 1750 In-stock
50 mg USD 2800 In-stock
100 mg USD 4500 In-stock
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Based on 1 publication(s) in Google Scholar

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Upacicalcet sodium Related Antibodies

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Description

Upacicalcet sodium is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT)[1].

IC50 & Target

calcium-sensing receptors[1]
Molecular Weight

373.75

Formula

C11H13ClN3NaO6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC[C@H](N)C(O[Na])=O)NC1=CC(S(=O)(O)=O)=CC(Cl)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (267.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6756 mL 13.3779 mL 26.7559 mL
5 mM 0.5351 mL 2.6756 mL 5.3512 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (161 KB) MS (175 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6756 mL 13.3779 mL 26.7559 mL 66.8896 mL
5 mM 0.5351 mL 2.6756 mL 5.3512 mL 13.3779 mL
10 mM 0.2676 mL 1.3378 mL 2.6756 mL 6.6890 mL
15 mM 0.1784 mL 0.8919 mL 1.7837 mL 4.4593 mL
20 mM 0.1338 mL 0.6689 mL 1.3378 mL 3.3445 mL
25 mM 0.1070 mL 0.5351 mL 1.0702 mL 2.6756 mL
30 mM 0.0892 mL 0.4459 mL 0.8919 mL 2.2297 mL
40 mM 0.0669 mL 0.3344 mL 0.6689 mL 1.6722 mL
50 mM 0.0535 mL 0.2676 mL 0.5351 mL 1.3378 mL
60 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
80 mM 0.0334 mL 0.1672 mL 0.3344 mL 0.8361 mL
100 mM 0.0268 mL 0.1338 mL 0.2676 mL 0.6689 mL
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Upacicalcet sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Upacicalcet2052969-18-1CaSRCalcium-sensing receptorcalcium-sensing receptorscalcimimetic agentparathyroid hormonePTHsecondary hyperparathyroidismSHPTInhibitorinhibitorinhibit

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