2. GPCR/G Protein
  3. CaSR
  4. (Rac)-Upacicalcet

(Rac)-Upacicalcet is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

For research use only. We do not sell to patients.

(Rac)-Upacicalcet Chemical Structure

(Rac)-Upacicalcet Chemical Structure

CAS No. : 2649575-19-7

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5 mg USD 870 In-stock
10 mg USD 1400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

(Rac)-Upacicalcet is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT)[1].

Molecular Weight

351.76

Formula

C11H14ClN3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC(N)C(O)=O)NC1=CC(S(=O)(O)=O)=CC(Cl)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (284.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8428 mL 14.2142 mL 28.4285 mL
5 mM 0.5686 mL 2.8428 mL 5.6857 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8428 mL 14.2142 mL 28.4285 mL 71.0712 mL
5 mM 0.5686 mL 2.8428 mL 5.6857 mL 14.2142 mL
10 mM 0.2843 mL 1.4214 mL 2.8428 mL 7.1071 mL
15 mM 0.1895 mL 0.9476 mL 1.8952 mL 4.7381 mL
20 mM 0.1421 mL 0.7107 mL 1.4214 mL 3.5536 mL
25 mM 0.1137 mL 0.5686 mL 1.1371 mL 2.8428 mL
30 mM 0.0948 mL 0.4738 mL 0.9476 mL 2.3690 mL
40 mM 0.0711 mL 0.3554 mL 0.7107 mL 1.7768 mL
50 mM 0.0569 mL 0.2843 mL 0.5686 mL 1.4214 mL
60 mM 0.0474 mL 0.2369 mL 0.4738 mL 1.1845 mL
80 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8884 mL
100 mM 0.0284 mL 0.1421 mL 0.2843 mL 0.7107 mL
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(Rac)-Upacicalcet Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Upacicalcet2649575-19-7CaSRCalcium-sensing receptorcalcium-sensing receptorscalcimimetic agentparathyroid hormonePTHsecondary hyperparathyroidismSHPTInhibitorinhibitorinhibit

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