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Gadopentetic acid  (Synonyms: Gd-DTPA; gadolinium complex)

Cat. No.: HY-107353 Purity: ≥99.0%
COA Handling Instructions

Gadopentetic acid (Gd-DTPA) is a paramagnetic contrast agent. Gadopentetic acid commonly implemented by a bolus intravenous injection in Dynamic contrast-enhanced MRI (DCE-MRI) studies. Gadopentetic acid also can be used for the research of nephrogenic systemic fibrosis (NSF).

For research use only. We do not sell to patients.

Gadopentetic acid Chemical Structure

Gadopentetic acid Chemical Structure

CAS No. : 80529-93-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
100 mg USD 50 In-stock
250 mg USD 90 In-stock
500 mg USD 130 In-stock
1 g   Get quote  
5 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gadopentetic acid (Gd-DTPA) is a paramagnetic contrast agent. Gadopentetic acid commonly implemented by a bolus intravenous injection in Dynamic contrast-enhanced MRI (DCE-MRI) studies. Gadopentetic acid also can be used for the research of nephrogenic systemic fibrosis (NSF)[1][2].

In Vivo

Gadopentetic acid (Gd-DTPA) (tail vein injection; 2 and 5mmol/kg; single) shows systematic metabolic responses involving changes in lipid metabolism, glucose metabolism, TCA cycle, amino acid metabolism and gut microbiota functions in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats[1]
Dosage: 2 and 5mmol/kg
Administration: tail vein injection, single
Result: Observed urinary and serum metabonomic recovery but the metabolic effects of high-dosed (5mmol/kg) lasted long.
Observed hyperlipidemia after Gd-DTPA injection.
Molecular Weight

547.57

Formula

C14H20GdN3O10

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[O-][Gd+3]23([O-]4)([O-]5)([O-]6)([O-]7)[N](CC[N]2(CC5=O)CC4=O)(CC[N]3(CC7=O)CC6=O)C1.[H+].[H+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (182.63 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8263 mL 9.1313 mL 18.2625 mL
5 mM 0.3653 mL 1.8263 mL 3.6525 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (182.63 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8263 mL 9.1313 mL 18.2625 mL 45.6563 mL
5 mM 0.3653 mL 1.8263 mL 3.6525 mL 9.1313 mL
10 mM 0.1826 mL 0.9131 mL 1.8263 mL 4.5656 mL
15 mM 0.1218 mL 0.6088 mL 1.2175 mL 3.0438 mL
20 mM 0.0913 mL 0.4566 mL 0.9131 mL 2.2828 mL
25 mM 0.0731 mL 0.3653 mL 0.7305 mL 1.8263 mL
30 mM 0.0609 mL 0.3044 mL 0.6088 mL 1.5219 mL
40 mM 0.0457 mL 0.2283 mL 0.4566 mL 1.1414 mL
50 mM 0.0365 mL 0.1826 mL 0.3653 mL 0.9131 mL
60 mM 0.0304 mL 0.1522 mL 0.3044 mL 0.7609 mL
80 mM 0.0228 mL 0.1141 mL 0.2283 mL 0.5707 mL
100 mM 0.0183 mL 0.0913 mL 0.1826 mL 0.4566 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gadopentetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Gadopentetic acid
Cat. No.:
HY-107353
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