1. GPCR/G Protein
  2. P2Y Receptor
  3. Cangrelor tetrasodium

Cangrelor tetrasodium 

Cat. No.: HY-19638A Purity: 99.93%
Handling Instructions

Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist.

For research use only. We do not sell to patients.

Cangrelor tetrasodium Chemical Structure

Cangrelor tetrasodium Chemical Structure

CAS No. : 163706-36-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 181 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist[1][2].

In Vitro

Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist[1].
Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3].

In Vivo

Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2].

Molecular Weight

864.29

Formula

C₁₇H₂₁Cl₂F₃N₅Na₄O₁₂P₃S₂

CAS No.

163706-36-3

SMILES

O=P(C(Cl)(P(O[Na])(O[Na])=O)Cl)(OP(OC[[email protected]]1O[[email protected]@H](N2C=NC3=C(NCCSC)N=C(SCCC(F)(F)F)N=C23)[[email protected]](O)[[email protected]@H]1O)(O[Na])=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References
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Keywords:

Cangrelor tetrasodiumP2Y ReceptorplateletaggregationinflammationpulmonaryfibrosisantiplateletintravenousInhibitorinhibitorinhibit

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Cangrelor tetrasodium
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