Cangrelor tetrasodium (Synonyms: AR-C69931MX tetrasodium)

Name: Cangrelor tetrasodium
Brand: MedChemExpress
SKU: HY-19638A
Rating: 5.0 (4 reviews)

Cat. No.: HY-19638A Pureté: 99.96%: Fiche technique
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SDS
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Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist.

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CAS No. : 163706-36-3

Size	Stock	Quantité

Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	Obtenir un devis
5 g	Obtenir un devis

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Based on 4 publication(s) in Google Scholar

Other Forms of Cangrelor tetrasodium:

Cangrelor Obtenir un devis
Cangrelor tetrasodium (Standard) Obtenir un devis

4 Publications Citing Use of MCE Cangrelor tetrasodium

ELISA

Cell Proliferation/Viability Assay

In Vivo Efficacy Study

: Cangrelor tetrasodium purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451. [Abstract]; Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC₅₀ values in Huh7 and Hep3B cells.

: Cangrelor tetrasodium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]; Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.

: Cangrelor tetrasodium purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]; The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.

: Cangrelor tetrasodium purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]; Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

Recommandations en vedette

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•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform P2Y Receptor:

Voir toutes les isoformes

P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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Description

IC₅₀ & Target

P2Y12 Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	0.4 1 Compound: cangrelor	Inhibition of ADP-induced platelet aggregation in human platelet rich plasma Inhibition of ADP-induced platelet aggregation in human platelet rich plasma	[PMID: 22531380]
Platelet	IC₅₀	0.4 1 Compound: cangrelor	Inhibition of ADP-induced platelet aggregation in human platelet rich plasma Inhibition of ADP-induced platelet aggregation in human platelet rich plasma	[PMID: 22531380]

In Vitro

Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist^[1].
? Cangrelor tetrasodium has pK_b of 8.6-9.2 for hP2Y12 receptor^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

Masse moléculaire

864.29

Formule

C₁₇H₂₁Cl₂F₃N₅Na₄O₁₂P₃S₂

CAS No.

163706-36-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@@H]1COP(OP(C(Cl)(P(O[Na])(O[Na])=O)Cl)(O[Na])=O)(O[Na])=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (115.70 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (14.46 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1570 mL	5.7851 mL	11.5702 mL
5 mM	0.2314 mL	1.1570 mL	2.3140 mL
10 mM	0.1157 mL	0.5785 mL	1.1570 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 1.25 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 1.25 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 1.25 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (115.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.96%

Select Batch:

Fiche technique (276 KB) SDS (393 KB)

COA (251 KB) HNMR (284 KB) CNMR (292 KB) RP-HPLC (205 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408. [Content Brief]

[2]. Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92. [Content Brief]

[3]. Bekő K, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain. J Thromb Haemost. 2017;15(6):1223-1235. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.1570 mL	5.7851 mL	11.5702 mL	28.9255 mL
	5 mM	0.2314 mL	1.1570 mL	2.3140 mL	5.7851 mL
	10 mM	0.1157 mL	0.5785 mL	1.1570 mL	2.8925 mL
H₂O	15 mM	0.0771 mL	0.3857 mL	0.7713 mL	1.9284 mL
	20 mM	0.0579 mL	0.2893 mL	0.5785 mL	1.4463 mL
	25 mM	0.0463 mL	0.2314 mL	0.4628 mL	1.1570 mL
	30 mM	0.0386 mL	0.1928 mL	0.3857 mL	0.9642 mL
	40 mM	0.0289 mL	0.1446 mL	0.2893 mL	0.7231 mL
	50 mM	0.0231 mL	0.1157 mL	0.2314 mL	0.5785 mL
	60 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.4821 mL
	80 mM	0.0145 mL	0.0723 mL	0.1446 mL	0.3616 mL
	100 mM	0.0116 mL	0.0579 mL	0.1157 mL	0.2893 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cangrelor tetrasodium Related Classifications

Inflammation/Immunology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cangrelor tetrasodium163706-36-3AR-C69931MX tetrasodiumP2Y ReceptorplateletaggregationinflammationpulmonaryfibrosisantiplateletintravenousInhibitorinhibitorinhibit

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Cangrelor tetrasodium (Synonyms: AR-C69931MX tetrasodium)

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Other Forms of Cangrelor tetrasodium:

Cangrelor tetrasodium Related Antibodies

4 Publications Citing Use of MCE Cangrelor tetrasodium

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform P2Y Receptor:

Activité biologique

Pureté et documentation

Références

Avis client

Cangrelor tetrasodium Related Antibodies

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Cangrelor tetrasodium Related Classifications

Keywords:

Vos produits récemment consultés:

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SAFETY DATA SHEET (SDS)

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