1. GPCR/G Protein
  2. P2Y Receptor
  3. Cangrelor tetrasodium

Cangrelor tetrasodium  (Synonyms: AR-C69931MX tetrasodium)

Cat. No.: HY-19638A Purity: 99.93%
COA Handling Instructions

Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist.

For research use only. We do not sell to patients.

Cangrelor tetrasodium Chemical Structure

Cangrelor tetrasodium Chemical Structure

CAS No. : 163706-36-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 181 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 181 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cangrelor tetrasodium:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cangrelor tetrasodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist[1][2].

IC50 & Target

P2Y12 Receptor

 

In Vitro

Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist[1].
Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

864.29

Formula

C17H21Cl2F3N5Na4O12P3S2

CAS No.
SMILES

O[[email protected]]1[[email protected]@H](O)[[email protected]](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[[email protected]@H]1COP(OP(C(Cl)(P(O[Na])(O[Na])=O)Cl)(O[Na])=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (144.63 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (14.46 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1570 mL 5.7851 mL 11.5702 mL
5 mM 0.2314 mL 1.1570 mL 2.3140 mL
10 mM 0.1157 mL 0.5785 mL 1.1570 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (115.70 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 1.25 mg/mL (1.45 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.93%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cangrelor tetrasodium
Cat. No.:
HY-19638A
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