2. GPCR/G Protein
  3. P2Y Receptor
  4. Cangrelor

Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Cangrelor tetrasodium) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No. : 163706-06-7

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Cangrelor Related Antibodies

Top Publications Citing Use of Products

    Cangrelor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451.  [Abstract]

    Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC50 values in Huh7 and Hep3B cells.

    Cangrelor purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381.  [Abstract]

    Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.

    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166.  [Abstract]

    The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.

    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166.  [Abstract]

    Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

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    Description

    Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist[1][2].

    IC50 & Target[1]

    P2Y12 Receptor

     

    In Vitro

    Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cangrelor Related Antibodies
    In Vivo

    Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    776.36

    Formula

    C17H25Cl2F3N5O12P3S2
    CAS No.
    SMILES

    CSCCNC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O)(O)=O)(O)=O)(O)=O)O3)C=N2)=NC(SCCC(F)(F)F)=N1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Cangrelor Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cangrelor163706-06-7AR-C69931MXP2Y ReceptorInhibitorinhibitorinhibit

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