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Cat. No.: HY-163345

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5-HT7R antagonist 2

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K_i of 67 nM, the IC₅₀ values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment.

For research use only. We do not sell to patients.

CAS No.: 1448808-50-1
Formula: C₁₆H₁₆N₂O
Molecular Weight:252.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

5-HT7R antagonist 2 Chemical Structure

CAS No.: 1448808-50-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

5-HT₇ Receptor

67 nM (Ki)

5-HT₇ Receptor

All 5-HT Receptor Isoforms :

In Vitro

5-HT7R antagonist 2 (compound 4h) (microsomes, 30 min) has significant metabolic stability and is not cytotoxic^[1].
5-HT7R antagonist 2 is a competitive antagonist in both G protein and β-arrestin signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Cell Line:
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In Vivo

5-HT7R antagonist (compound 4h) (intraperitoneal injection, 5 mg/kg, 30 min) has the potential to regulate the repetitive behavior of ASD in the animal model of ASD, and can increase the number of immature ASD neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ASD animal models
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection
Result:

4h can increase the number of immature ASD neurons

Chemical Information

CAS No. 1448808-50-1
Molecular Weight 252.31
Formula C₁₆H₁₆N₂O
SMILES

COC1=C(C2=CC=CC(C3=NCCN3)=C2)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15(5):1026-1041. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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5-HT7R antagonist 2

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-HT7R antagonist 2 Related Classifications

HY-163345 Related Classifications