1448808-50-1
1448808-50-1
Chemical Structure
5-HT7R antagonist 2
- CAS No.: 1448808-50-1
- Formula:C16H16N2O
- Molecular Weight:252.31
InChIKey: CQKVUQYWPBSBGU-UHFFFAOYSA-N
SMILES: COC1=C(C2=CC=CC(C3=NCCN3)=C2)C=CC=C1
Biological Activity: 5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].
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5-HT7R antagonist 2 | 5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment. | |||||||||||||||||||||
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References
Keywords
