GR 83074
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.
For research use only. We do not sell to patients.
- CAS No.: 141636-44-4
- Formula: C50H72N12O9
- Molecular Weight:985.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
In the isolated rat colon and guinea-pig trachea, GR 83074 is a potent competitive antagonist of the contractions induced by the selective NK-2 agonist GR6434[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141636-44-4
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Molecular Weight 985.18
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Formula C50H72N12O9
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Sequence
{Boc}-Arg-Ala-{D-Trp}-Phe-{D-Pro}-Pro-{Nle}-NH2
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Sequence Shortening
{Boc}-RA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR 83074 Related Classifications
HY-P3854 Related Classifications
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