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(R)-Thalidomide (Synonyms: (R)-(+)-Thalidomide)

Cat. No.: HY-14658B
Handling Instructions

(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has sedative properties.

For research use only. We do not sell to patients.

(R)-Thalidomide Chemical Structure

(R)-Thalidomide Chemical Structure

CAS No. : 2614-06-4

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Description

(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has sedative properties[1][2].

In Vitro

The transport of the (R)-Thalidomide from the R-imprinted MIP-1 through the donor phase to the receiver phase is much less owing to the stronger retention of the thalidomide in the organic phase. With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities[1].
The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs[1].

In Vivo

Adult female F344 rats are implanted with 9L gliosarcoma tumours intracranially, subcutaneously (flank), or both. Effectiveness of oral thalidomide alone, and with intraperitoneal BCNU or cisplatin combination chemotherapy, is assessed after several weeks treatment. Both serum and tissue concentrations of (R)-thalidomide are 40-50% greater than those of (S)-thalidomide. Co-administration of BCNU or cisplatin with thalidomide did not alter the concentration enantioselectivity[1].

Molecular Weight

258.23

Formula

C₁₃H₁₀N₂O₄

CAS No.

2614-06-4

SMILES

O=C1N([[email protected]](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(R)-Thalidomide(R)-(+)-ThalidomideOthersAnti-angiogenicracemateanti-tumourenantiomersintravenouslysedativeInhibitorinhibitorinhibit

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