1. PROTAC
    Autophagy
    Apoptosis
  2. Ligand for E3 Ligase
    Autophagy
    Apoptosis
  3. Thalidomide D4

Thalidomide D4 

Cat. No.: HY-14658S
Handling Instructions

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.

For research use only. We do not sell to patients.

Thalidomide D4 Chemical Structure

Thalidomide D4 Chemical Structure

CAS No. : 1219177-18-0

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Description

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

IC50 & Target

Kd: ~250 nM (CRL4CRBN)[1]

Molecular Weight

262.25

Formula

C₁₃H₆D₄N₂O₄

CAS No.

1219177-18-0

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Thalidomide D4Thalidomide D 4Thalidomide D-4Ligand for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyDeuteriumlabeledcereblonCUL4-RBX1-DDB1immunomodulatoryanti-inflammatoryanti-angiogeniccancerInhibitorinhibitorinhibit

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