1. PROTAC
    Autophagy
    Apoptosis
  2. Ligands for E3 Ligase
    Molecular Glues
    Autophagy
    Apoptosis
  3. Thalidomide D4

Thalidomide D4 

Cat. No.: HY-14658S Purity: 98.03%
COA Handling Instructions

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.

For research use only. We do not sell to patients.

Thalidomide D4 Chemical Structure

Thalidomide D4 Chemical Structure

CAS No. : 1219177-18-0

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1 mg USD 650 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1875 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

IC50 & Target

Kd: ~250 nM (CRL4CRBN)[1]

Molecular Weight

262.25

Formula

C13H6D4N2O4

CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Thalidomide D4
Cat. No.:
HY-14658S
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