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  4. Bevonescein

Bevonescein  (Synonyms: ALM-488)

Cat. No.: HY-P4154 Purity: 99.75%
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Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bevonescein Chemical Structure

Bevonescein Chemical Structure

CAS No. : 2276787-79-0

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 330 In-stock
10 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

Bevonescein Related Antibodies

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Description

Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves[1][2].

In Vivo

Bevonescein (ALM-488; 900 nmol; IV; underwent a 90-minute observation period) improves nerve identification for intact, degenerated, and partially regenerated nerves by vivo realtime fluorescence imaging (FL) in female SKH‐1 hairless, wild‐type, ~25 g mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

2310.47

Formula

C112H144N22O32
CAS No.
Appearance

Solid

Color

Yellow to orange

Sequence

(5-FAM)-Gln-Val-Pro-Trp-Glu-Glu-Pro-Tyr-Tyr-Val-Val-Lys-Lys-Ser-Ser-Gly-Gly-(C-terminal amide)
Sequence Shortening

(5-FAM)-QVPWEEPYYVVKKSSGG(C-terminal amide)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (43.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4328 mL 2.1641 mL 4.3281 mL
5 mM 0.0866 mL 0.4328 mL 0.8656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4328 mL 2.1641 mL 4.3281 mL 10.8203 mL
5 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1641 mL
10 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
15 mM 0.0289 mL 0.1443 mL 0.2885 mL 0.7214 mL
20 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5410 mL
25 mM 0.0173 mL 0.0866 mL 0.1731 mL 0.4328 mL
30 mM 0.0144 mL 0.0721 mL 0.1443 mL 0.3607 mL
40 mM 0.0108 mL 0.0541 mL 0.1082 mL 0.2705 mL
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Bevonescein Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bevonescein2276787-79-0ALM-488ALM488ALM 488Fluorescent DyeIntravenouslyfluorescein-conjugated peptidenerveconnective tissueperipheral nervesreal-time fluorescence imagingFLdegenerated nervesInhibitorinhibitorinhibit

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