2276787-79-0
Chemical Structure
Bevonescein
Synonym(s): ALM-488
- CAS No.: 2276787-79-0
- Formula:C112H144N22O32
- Molecular Weight:2310.47
IUPAC Name: (2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl-5,5-d2)methan-d2-ol
SMILES: O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N6[C@@H](CCC6)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N7[C@@H](CCC7)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)CC9=CC=C(C=C9)O)=O)=O)=O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O)C=C51
Biological Activity: Bevonescein (ALM-488) is a fluorescein-conjugated peptide that facilitates the targeted delivery of a fluorescent moiety (5-FAM (HY-66022)) to nerves after intravenous (IV) administration. Bevonescein binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves (Ex/Em = 480/530 nm)[1][2][3].
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Bevonescein | 99.11% | Bevonescein (ALM-488) is a fluorescein-conjugated peptide that facilitates the targeted delivery of a fluorescent moiety (5-FAM (HY-66022)) to nerves after intravenous (IV) administration. Bevonescein binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves (Ex/Em = 480/530 nm). | ||||||||||||||||||||
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- [1]. Kayva L Crawford, et al. Identification of Degenerated Murine Facial Nerves With Fluorescence Labeling After Transection Injury. Otolaryngol Head Neck Surg. 2023 Aug;169(2):234-242. [Content Brief]
- [2]. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901. Feredun Azari, et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings. J Biomed Opt. 2021 May;26(5):050901. [Content Brief]
- [3]. Whitney, M.A. et al. Bevonescein-A Peptide Dye Conjugate for Visualization of Peripheral Nerves in Patients During Surgery. Future Pharmacol. 2026, 6, 13.
Keywords
