1. Apoptosis
  2. Apoptosis
  3. Etidronic acid

Etidronic acid (Synonyms: Etidronate; HEDPA; HEDP)

Cat. No.: HY-B0302 Purity: ≥98.0%
Handling Instructions

Etidronic acid (Etidronate) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.

For research use only. We do not sell to patients.

Etidronic acid Chemical Structure

Etidronic acid Chemical Structure

CAS No. : 2809-21-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 80 In-stock
Estimated Time of Arrival: December 31
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Description

Etidronic acid (Etidronate) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.

In Vitro

Etidronic acid (1 nM-1000 nM) reduces both the total pit area and pit number in a dose-dependent manner in osteoclasts, it directly inhibits bone-resorbing activity in mature osteoclasts, and it reduces the osteoclast and/or adhesion activity of osteoclasts on dentines[1].
Etidronic acid (100 nM; 24 hours) induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

206.03

Formula

C2H8O7P2

CAS No.
SMILES

OC(P(O)(O)=O)(P(O)(O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (485.37 mM; Need ultrasonic)

DMSO : 100 mg/mL (485.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8537 mL 24.2683 mL 48.5366 mL
5 mM 0.9707 mL 4.8537 mL 9.7073 mL
10 mM 0.4854 mL 2.4268 mL 4.8537 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (485.37 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.13 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.13 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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  • Molarity Calculator

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Product Name:
Etidronic acid
Cat. No.:
HY-B0302
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