1. Immunology/Inflammation
    Anti-infection
  2. Toll-like Receptor (TLR)
    HBV
  3. Selgantolimod

Selgantolimod (Synonyms: GS-9688)

Cat. No.: HY-109137
Handling Instructions

Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection.

For research use only. We do not sell to patients.

Selgantolimod Chemical Structure

Selgantolimod Chemical Structure

CAS No. : 2004677-13-6

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Description

Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection[1][2][3].

IC50 & Target[1][2]

TLR8

 

HBV

 

In Vitro

Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and interferon-γ (IFNγ) in vitro in human perpheral blood mononuclear cells[1].
Selgantolimod activates natural killer (NK) and mucosal associated invariant T cells, stimulates cluster of differentiation (CD)-8+ T-cell proliferation, and increas IFNγ production, while lowering programmed cell death protein 1 expression by HBV-specific CD8+-T cells in vitro in peripheral blood mononuclear cells[1].
Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes[1].

In Vivo

Once-weekly dosing of oral Selgantolimod induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys, and leads to functional cure in the woodchuck model of chronic HBV[1].

Clinical Trial
Molecular Weight

293.34

Formula

C₁₄H₂₀FN₅O

CAS No.

2004677-13-6

SMILES

C[[email protected]@](CCCC)(CO)NC1=NC(N)=NC2=C1N=CC(F)=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SelgantolimodGS-9688GS9688GS 9688Toll-like Receptor (TLR)HBVHepatitis B virusHepatitisimmunomodulatorviruswell-toleratedsafecytokinesinterleukin IL-1RAinterferon-γInhibitorinhibitorinhibit

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Selgantolimod
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