2. Others NF-κB Apoptosis
  3. NF-κB Apoptosis Isotope-Labeled Compounds
  4. Laquinimod-d5

Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research.

For research use only. We do not sell to patients.

Laquinimod-d<sub>5</sub> Chemical Structure

Laquinimod-d5 Chemical Structure

CAS No. : 1214267-09-0

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1 mg USD 480 In-stock
5 mg USD 1150 In-stock
10 mg USD 1850 In-stock
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Laquinimod-d5 Related Antibodies

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Description

Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research[1].

Molecular Weight

361.83

Formula

C19H12D5ClN2O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[2H]C1=C([2H])C([2H])=C(N(C(C2=C(O)C3=C(N(C)C2=O)C=CC=C3Cl)=O)CC)C([2H])=C1[2H]
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (276.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7637 mL 13.8186 mL 27.6373 mL
5 mM 0.5527 mL 2.7637 mL 5.5275 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7637 mL 13.8186 mL 27.6373 mL 69.0932 mL
5 mM 0.5527 mL 2.7637 mL 5.5275 mL 13.8186 mL
10 mM 0.2764 mL 1.3819 mL 2.7637 mL 6.9093 mL
15 mM 0.1842 mL 0.9212 mL 1.8425 mL 4.6062 mL
20 mM 0.1382 mL 0.6909 mL 1.3819 mL 3.4547 mL
25 mM 0.1105 mL 0.5527 mL 1.1055 mL 2.7637 mL
30 mM 0.0921 mL 0.4606 mL 0.9212 mL 2.3031 mL
40 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7273 mL
50 mM 0.0553 mL 0.2764 mL 0.5527 mL 1.3819 mL
60 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1516 mL
80 mM 0.0345 mL 0.1727 mL 0.3455 mL 0.8637 mL
100 mM 0.0276 mL 0.1382 mL 0.2764 mL 0.6909 mL
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Laquinimod-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laquinimod-d51214267-09-0ABR-215062-d5NF-κBApoptosisIsotope-Labeled CompoundsNuclear factor-κBNuclear factor-kappaBCarboxamideImmunomodulatorElapsing remittingChronic progressiveMultiple sclerosisNeurodegenerative diseaseInhibitorinhibitorinhibit

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