1. Anti-infection
  2. Parasite
    HSV
  3. Levamisole hydrochloride

Levamisole hydrochloride (Synonyms: (-)-Tetramisole hydrochloride)

Cat. No.: HY-13666 Purity: 99.96%
Handling Instructions

Levamisole hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV.

For research use only. We do not sell to patients.

Levamisole hydrochloride Chemical Structure

Levamisole hydrochloride Chemical Structure

CAS No. : 16595-80-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g USD 96 In-stock
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50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Levamisole hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV.

In Vitro

Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging.

Molecular Weight

240.75

Formula

C₁₁H₁₃ClN₂S

CAS No.

16595-80-5

SMILES

[H]Cl.C12=N[[email protected]@H](C3=CC=CC=C3)CN1CCS2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (207.68 mM; Need ultrasonic)

DMSO : 15.5 mg/mL (64.38 mM; Need ultrasonic and warming)

Ethanol : 12.5 mg/mL (51.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1537 mL 20.7684 mL 41.5369 mL
5 mM 0.8307 mL 4.1537 mL 8.3074 mL
10 mM 0.4154 mL 2.0768 mL 4.1537 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (5.19 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 1.25 mg/mL (5.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Keywords:

Levamisole(-)-TetramisoleParasiteHSVHerpes simplex virusInhibitorinhibitorinhibit

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Product name:
Levamisole hydrochloride
Cat. No.:
HY-13666
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