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  4. Inosine pranobex

Inosine pranobex  (Synonyms: Imunovir; Delimmun; Groprinosin)

Cat. No.: HY-107801 Purity: 99.89%
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Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

For research use only. We do not sell to patients.

Inosine pranobex Chemical Structure

Inosine pranobex Chemical Structure

CAS No. : 36703-88-5

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10 mM * 1 mL in DMSO
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Based on 2 publication(s) in Google Scholar

Inosine pranobex Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Inosine pranobex

WB

    Inosine pranobex purchased from MedChemExpress. Usage Cited in: Viruses. 2018 Apr 17;10(4). pii: E201.  [Abstract]

    After incubation with PGG and IPS, RABV is inoculated with BHK-21 cells for 48 h, and the expression level of viral P is analyzed by Western blotting.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus [2][3][4][5].

    In Vitro

    Inosine pranobex (50-200 mg/L; 24-72 h) significantly increases the secretion of TNF-α and IFN-γ (72 h) in lymphocytes, and inhibites IL-10 stimulated by PHA (5 mg/L) to produce lymphocytes, showing immunomodulatory properties[2].
    Inosine pranobex (50-800 μg/mL; 48 h) can reduce the titer of HAdV-2 (IC50=1743.8 μg/mL) and HAdV-5 (IC50=1304.5 μg/mL) in A549 cells, and strongly inhibit the proliferation of the virus at high concentrations[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Inosine pranobex Related Antibodies
    Clinical Trial
    Molecular Weight

    1115.23

    Formula

    C52H78N10O17
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(NC1=CC=C(C(O)=O)C=C1)=O.CC(NC2=CC=C(C(O)=O)C=C2)=O.CC(O)CN(C)C.O[C@H]3[C@@H](O[C@H](CO)[C@H]3O)N4C5=C(C(N=CN5)=O)N=C4.CC(O)CN(C)C.CC(O)CN(C)C.CC(NC6=CC=C(C(O)=O)C=C6)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (56.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8967 mL 4.4834 mL 8.9668 mL
    5 mM 0.1793 mL 0.8967 mL 1.7934 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (1.87 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (1.87 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.8967 mL 4.4834 mL 8.9668 mL 22.4169 mL
    5 mM 0.1793 mL 0.8967 mL 1.7934 mL 4.4834 mL
    10 mM 0.0897 mL 0.4483 mL 0.8967 mL 2.2417 mL
    15 mM 0.0598 mL 0.2989 mL 0.5978 mL 1.4945 mL
    20 mM 0.0448 mL 0.2242 mL 0.4483 mL 1.1208 mL
    25 mM 0.0359 mL 0.1793 mL 0.3587 mL 0.8967 mL
    30 mM 0.0299 mL 0.1494 mL 0.2989 mL 0.7472 mL
    40 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5604 mL
    50 mM 0.0179 mL 0.0897 mL 0.1793 mL 0.4483 mL
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    Inosine pranobex Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Inosine pranobex36703-88-5Imunovir Delimmun GroprinosinInterleukin RelatedHSVHIVHPVILHerpes simplex virusHuman immunodeficiency virusHuman papillomavirusImmunomodulatoryAntiviralLymphocyteSSPEVACVINFVPIVEBCytomegalovirusA549Inhibitorinhibitorinhibit

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