1. Metabolic Enzyme/Protease
    Autophagy
    Anti-infection
  2. Phosphodiesterase (PDE)
    Autophagy
    HIV
  3. Pentoxifylline

Pentoxifylline (Synonyms: BL-191; PTX; Oxpentifylline)

Cat. No.: HY-B0715 Purity: 99.91%
Handling Instructions

Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.

For research use only. We do not sell to patients.

Pentoxifylline Chemical Structure

Pentoxifylline Chemical Structure

CAS No. : 6493-05-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

IC50 & Target

PDE[1]

In Vitro

Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner[3].
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase[3].
Pentoxifylline results in high LC3-II/LC3-ratio[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM
Incubation Time: 24 hours, 48 hours
Result: Inhibited cell proliferation in a dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 12 hours, 24 hours, 36 hours
Result: Induced apoptosis.

Apoptosis Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced approximately 20-28% of cell autophagy.

Cell Cycle Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced G0/G1 phase arrest.

Western Blot Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced high LC3-II/LC3-ratio.
In Vivo

Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and could reduce cognitive impairment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats 12-13-weeks-old (250-300 g)[4]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection, at 1hr before and 3 hr after ischemia
Result: Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.
Clinical Trial
Molecular Weight

278.31

Formula

C₁₃H₁₈N₄O₃

CAS No.

6493-05-6

SMILES

O=C(N1CCCCC(C)=O)N(C)C2=C(N(C)C=N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 93.3 mg/mL (335.24 mM; Need ultrasonic and warming)

DMSO : ≥ 2.8 mg/mL (10.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5931 mL 17.9656 mL 35.9312 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL
10 mM 0.3593 mL 1.7966 mL 3.5931 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (395.24 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

PentoxifyllineBL-191 PTX OxpentifyllineBL191BL 191Phosphodiesterase (PDE)AutophagyHIVHuman immunodeficiency virusmethyl-xanthineintermittentclaudicationimmunomodulatorhemorheologicalhemorrheologicdermatologicalperipheral vasculardiseasesvasculopathiesvasculitidesvenouslegulcerspigmentedpurpuricdermatosesleprosyanti-hypercholesterolemicInhibitorinhibitorinhibit

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