1. Metabolic Enzyme/Protease
    Autophagy
  2. Phosphodiesterase (PDE)
    Autophagy

Pentoxifylline (Synonyms: PTX; Oxpentifylline)

Cat. No.: HY-B0715 Purity: 99.91%
Handling Instructions

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.

For research use only. We do not sell to patients.

Pentoxifylline Chemical Structure

Pentoxifylline Chemical Structure

CAS No. : 6493-05-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor. Target: PDE Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors [1]. Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account [2]. Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue [3].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 93.3 mg/mL (335.24 mM; Need ultrasonic and warming)

DMSO : ≥ 2.8 mg/mL (10.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5931 mL 17.9656 mL 35.9312 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL
10 mM 0.3593 mL 1.7966 mL 3.5931 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

278.31

Formula

C₁₃H₁₈N₄O₃

CAS No.

6493-05-6

SMILES

O=C(N1CCCCC(C)=O)N(C)C2=C(N(C)C=N2)C1=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Pentoxifylline
Cat. No.:
HY-B0715
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Pentoxifylline

Cat. No.: HY-B0715