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  2. HKOCl-4

HKOCl-4 (Synonyms: BXY2142)

Cat. No.: HY-130027
Handling Instructions

HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.

For research use only. We do not sell to patients.

HKOCl-4 Chemical Structure

HKOCl-4 Chemical Structure

CAS No. : 2031170-85-9

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Description

HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity[1]. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.

IC50 & Target

Ex: 530 nm; Em 557 nm

In Vitro

HKOCl-4 (10 μM) shows an increasing florescence intensity with increasing concentration of hypochlorous acid[1].
HKOCl-4 exhibits a ultra-fast response towards 1 equiv of HOCl (reached a plateau within 2 min) , and it shows a >20-fold increase in fluorescence intensity over other analytes (1 equiv of •OH and ONOO− as well as 10 equiv of O2, NO, 1O2, ROO•, TBHP and H2O2)[2].
HKOCl-4 is first tested and it was proven to be non-toxic in living cells even at a concentration up to 50 µM in RAW264.7 macrophages[2].

Molecular Weight

688.59

Formula

C₃₈H₃₅Cl₂NO₇

CAS No.

2031170-85-9

SMILES

O=C(OCC)CCCN1C(C)(C)CC(C)C2=C1C=C3C(C4(OC(C5=C4C=CC=C5)=O)C6=CC=C(OC7=CC(Cl)=C(O)C(Cl)=C7)C=C6O3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HKOCl-4BXY2142HKOCl4HKOCl 4BXY 2142BXY-2142OthersHOClrhodol-basedFluorescent Probehypochlorous acidO2NO1O2ROO?TBHPInhibitorinhibitorinhibit

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HKOCl-4
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HY-130027
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