1. Metabolic Enzyme/Protease
  2. Phospholipase
    MAGL
  3. 7-Hydroxycoumarinyl arachidonate

7-Hydroxycoumarinyl arachidonate (Synonyms: 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate)

Cat. No.: HY-116141
Handling Instructions

7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer.

For research use only. We do not sell to patients.

7-Hydroxycoumarinyl arachidonate Chemical Structure

7-Hydroxycoumarinyl arachidonate Chemical Structure

CAS No. : 161180-11-6

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Description

7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].

In Vitro

MAGL catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonate (7-HCA) into arachidonic acid (AA) and 7-HC. Release of 7-HC, which is fluorescent, is monitored over time with excitation (Ex) at 355 nm and emission (Em) at 460 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

448.59

Formula

C₂₉H₃₆O₄

CAS No.

161180-11-6

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC1=CC=C2C=CC(OC2=C1)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

7-Hydroxycoumarinyl arachidonate7-HCA Umbelliferyl Arachidonate 7-HC-arachidonatePhospholipaseMAGLMonoacylglycerol lipasePLA2Arachidonicacid7-hydroxylcoumarin7-HCfluorometerInhibitorinhibitorinhibit

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Product Name:
7-Hydroxycoumarinyl arachidonate
Cat. No.:
HY-116141
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