2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. P-CAB agent 2

P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.

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P-CAB agent 2 Chemical Structure

P-CAB agent 2 Chemical Structure

CAS No. : 1978371-23-1

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Based on 1 publication(s) in Google Scholar

Other Forms of P-CAB agent 2:

P-CAB agent 2 Related Antibodies

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Description

P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].

In Vitro

P-CAB agent 2 (100 µM) inhibits the hERG potassium channel with an inhibition rate of 86.21% and an IC50 value of 18.69 M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P-CAB agent 2 Related Antibodies
In Vivo

P-CAB agent 2 (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 180-220 g, SPF grade, male SD rats[1]
Dosage: 2 mg/kg
Administration: P.o.; once
Result: Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.
Molecular Weight

432.51

Formula

C22H25FN2O4S
CAS No.
Appearance

Oil

Color

Light brown to brown

SMILES

O=S(C1=CC(OCCCOC)=CC=C1)(N2C=C(CNC)C=C2C3=C(F)C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3121 mL 11.5604 mL 23.1209 mL
5 mM 0.4624 mL 2.3121 mL 4.6242 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3121 mL 11.5604 mL 23.1209 mL 57.8021 mL
5 mM 0.4624 mL 2.3121 mL 4.6242 mL 11.5604 mL
10 mM 0.2312 mL 1.1560 mL 2.3121 mL 5.7802 mL
15 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8535 mL
20 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8901 mL
25 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3121 mL
30 mM 0.0771 mL 0.3853 mL 0.7707 mL 1.9267 mL
40 mM 0.0578 mL 0.2890 mL 0.5780 mL 1.4451 mL
50 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
60 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9634 mL
80 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7225 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5780 mL
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P-CAB agent 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-CAB agent 21978371-23-1Potassium ChannelKcsAhistaminehERG potassium channelacute toxicitygastric acidorally activeInhibitorinhibitorinhibit

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P-CAB agent 2
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