1. GPCR/G Protein
  2. Vasopressin Receptor
  3. JKC 301

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking.

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JKC 301 Chemical Structure

JKC 301 Chemical Structure

CAS No. : 136553-96-3

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Description

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].

IC50 & Target

Endothelin A receptor[1][2].

Molecular Weight

624.73

Formula

C32H44N6O7

CAS No.
Sequence

Cyclo({d-Asp}-Pro-{d-Ile}-Leu-{d-Trp})

Sequence Shortening

Cyclo({d-Asp}-P-{d-Ile}-L-{d-Trp})

SMILES

O=C(N[C@@H](C(N(CCC1)[C@]1([H])C2=O)=O)CC(O)=O)[C@H](NC([C@@H](NC([C@@](N2)([H])[C@H](C)CC)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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JKC 301
Cat. No.:
HY-P4201
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